Preliminary evaluation of a molecular imprinted polymer for solid-phase extraction of tamoxifen

被引：89
作者：
Rashid, BA
Briggs, RJ
Hay, JN
Stevenson, D
机构：
[1] UNIV SURREY,ROBENS INST,GUILDFORD GU2 5XH,SURREY,ENGLAND
[2] UNIV SURREY,DEPT CHEM,GUILDFORD GU2 5XH,SURREY,ENGLAND
来源：
ANALYTICAL COMMUNICATIONS | 1997年 / 34卷 / 10期
关键词：
D O I：
10.1039/a705884e
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A molecular imprinted polymer, prepared around a tamoxifen template, has been synthesised. The feasibility of using this polymer for solid-phase extraction of tamoxifen from biological samples has been investigated. The results show that the drug can be quantitatively retained and eluted from the polymer using acetonitrile-acetic acid. Experiments with biological fluids indicate that clean traces are obtained for HPLC with UV detection using this type of protocol.
引用
收藏
页码：303 / 305
页数：3
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