RGS9, a GTPase accelerator for phototransduction

被引：290
作者：
He, W
Cowan, CW
Wensel, TG [1 ]
机构：
[1] Baylor Coll Med, Verna & Marrs Mclean Dept Biochem, Houston, TX 77030 USA
[2] Baylor Coll Med, Grad Program Cell & Mol Biol, Houston, TX 77030 USA
来源：
NEURON | 1998年 / 20卷 / 01期
关键词：
D O I：
10.1016/S0896-6273(00)80437-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The rod outer segment phototransduction GAP (GTPase-accelerating protein) has been identified as RGS9, a member of the RGS family of Ga GAPs. RGS9 mRNA expression is specific for photoreceptor cells, and RGS9 protein colocalizes with other phototransduction components to photoreceptor outer segment membranes. The RGS domain of RGS9 accelerates GTP hydrolysis by the visual G protein transducin (G alpha(t)), and this acceleration is enhanced by the gamma subunit of the phototransduction effector cGMP phosphodiesterase (PDEgamma). These unique properties of RGS9 match those of the rod outer segment GAP and implicate it as a key element in the recovery phase of visual transduction.
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页码：95 / 102
页数：8
相关论文
共 45 条
[1]  
Albrecht UEG, 1997, MOL CELLULAR METHODS, P23
[2]   A GTPASE-ACCELERATING FACTOR FOR TRANSDUCIN, DISTINCT FROM ITS EFFECTOR CGMP PHOSPHODIESTERASE, IN ROD OUTER SEGMENT MEMBRANES [J].
ANGLESON, JK ;
WENSEL, TG .
NEURON, 1993, 11 (05) :939-949
[3]  
ANGLESON JK, 1994, J BIOL CHEM, V269, P16290
[4]   GTP HYDROLYSIS BY PURIFIED ALPHA-SUBUNIT OF TRANSDUCIN AND ITS COMPLEX WITH THE CYCLIC-GMP PHOSPHODIESTERASE INHIBITOR [J].
ANTONNY, B ;
OTTOBRUC, A ;
CHABRE, M ;
VUONG, TM .
BIOCHEMISTRY, 1993, 32 (33) :8646-8653
[5]   TRANSDUCIN GTPASE PROVIDES FOR RAPID QUENCHING OF THE CGMP CASCADE IN ROD OUTER SEGMENTS [J].
ARSHAVSKY, VY ;
ANTOCH, MP ;
LUKJANOV, KA ;
PHILIPPOV, PP .
FEBS LETTERS, 1989, 250 (02) :353-356
[6]   ON THE ROLE OF TRANSDUCIN GTPASE IN THE QUENCHING OF A PHOSPHODIESTERASE CASCADE OF VISION [J].
ARSHAVSKY, VY ;
ANTOCH, MP ;
PHILIPPOV, PP .
FEBS LETTERS, 1987, 224 (01) :19-22
[7]   REGULATION OF DEACTIVATION OF PHOTORECEPTOR G-PROTEIN BY ITS TARGET ENZYME AND CGMP [J].
ARSHAVSKY, VY ;
BOWNDS, MD .
NATURE, 1992, 357 (6377) :416-417
[8]  
ARSHAVSKY VY, 1994, J BIOL CHEM, V269, P19882
[9]   THE PHOTOCURRENT, NOISE AND SPECTRAL SENSITIVITY OF RODS OF THE MONKEY MACACA-FASCICULARIS [J].
BAYLOR, DA ;
NUNN, BJ ;
SCHNAPF, JL .
JOURNAL OF PHYSIOLOGY-LONDON, 1984, 357 (DEC) :575-607
[10]   GAIP and RGS4 are GTPase-activating proteins for the G(i) subfamily of G protein alpha subunits [J].
Berman, DM ;
Wilkie, TM ;
Gilman, AG .
CELL, 1996, 86 (03) :445-452
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