Rh(i)- and Rh(ii)-catalyzed C-H alkylation of benzylamines with alkenes and its application in flow chemistry

被引：10

作者：

Das, Amrita ^{[1
]}

Chatani, Naoto ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

来源：

CHEMICAL SCIENCE | 2021年 / 12卷 / 09期

关键词：

RHODIUM-CATALYZED ALKYLATION; AROMATIC AMIDES; BOND FUNCTIONALIZATION; POSSIBLE GENERATION; OXIDATIVE ADDITION; DIRECTING GROUPS; CARBENE COMPLEX; ACTIVATION; DERIVATIVES; PICOLINAMIDE;

D O I：

10.1039/d0sc05813k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Rh-catalyzed C-H alkylation of benzylamines with alkenes using a picolinamide derivative as a directing group is reported. Both Rh(i) and Rh(ii) complexes can be used as active catalysts for this transformation. In addition, a flow set up was designed to successfully mimic this process under flow conditions. Several examples are presented under flow conditions and it was confirmed that a flow process is advantageous over a batch process. Deuterium labelling experiments were performed to elucidate the mechanism of the reaction, and the results indicated a possible carbene mechanism for this C-H alkylation process.

引用

页码：3202 / 3209

页数：8

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