M2 macrophage-targeted iron oxide nanoparticles for magnetic resonance image-guided magnetic hyperthermia therapy

被引：34

作者：

Wang, Wenshen ^{[1
,2
]}

Li, Fenfen ^{[1
,2
]}

Li, Shibo ^{[1
,2
]}

Hu, Yi ^{[1
,2
]}

Xu, Mengran ^{[3
]}

Zhang, Yuanyuan ^{[1
,2
]}

Khan, Muhammad Imran ^{[1
,2
]}

Wang, Shaozhen ^{[1
,2
]}

Wu, Min ^{[3
]}

Ding, Weiping ^{[1
,2
]}

Qiu, Bensheng ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China

[2] Univ Sci & Technol China, Ctr Biomed Engn, Hefei 230027, Peoples R China

[3] Anhui Med Univ, Affiliated Hosp 1, Hefei 230022, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | 2021年 / 81卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

M2 macrophages-targeted peptide; Iron oxide nanoparticles; Magnetic resonance imaging; Magnetic hyperthermia therapy; Tumor immune microenvironment; TUMOR-ASSOCIATED MACROPHAGES; MRI CONTRAST; MONOCLONAL-ANTIBODY; CANCER-THERAPY; POLARIZATION; RECEPTOR; MECHANISMS; CYTOKINE; DELIVERY; GROWTH;

D O I：

10.1016/j.jmst.2020.11.058

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Tumor-associated macrophages (TAMs) play an important role in tumor development and progression. In particular, M2 TAMs can promote tumor growth by facilitating tumor progression and malignant behaviors. Selectively targeted elimination of M2 TAMs to inhibit tumor progression is of great significance for cancer treatment. Iron oxide nanoparticles based magnetic hyperthermia therapy (MHT) is a classical approach to destroy tumor tissue with deep penetration depth. In this study, we developed a typical M2 macrophage-targeted peptide (M2pep) functionalized superparamagnetic iron oxide nanoparticle (SPIO) for magnetic resonance imaging (MRI)-guided MHT in an orthotopic breast cancer mouse model. The obtained multifunctional SPIO-M2pep with a hydrodynamic diameter of 20 nm showed efficient targeting capability, high transverse relaxivity (149 mM(-1) s(-1)) and satisfactory magnetic hyperthermia performance in vitro. In vivo studies demonstrated that the SPIO-M2pep based MRI can monitor the distribution of nanoparticles in tumor and indicate the suitable timing for MHT. The M2 macrophage-targeted MHT significantly reduced the tumor volume and the population of pro-tumoral M2 TAMs in tumor. In addition, the SPIO-M2pep based MHT can remodel the tumor immune microenvironment (TIME). The multifunctional SPIO-M2pep with M2 macrophage-targeting ability, high magnetic hyperthermia efficiency, MR imaging capability and effective role in remodeling the TIME hold great potential to improve clinical cancer therapy outcomes. (C) 2021 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.

引用

页码：77 / 87

页数：11