Challenges facing the drug discovery pipeline for non-tuberculous mycobacteria

被引：42
作者：
Soni, Isha [1 ]
De Groote, Mary Ann [2 ]
Dasgupta, Arunava [1 ]
Chopra, Sidharth [1 ]
机构：
[1] CSIR Cent Drug Res Inst, Div Microbiol, Sect 10, Sitapur Rd, Lucknow 226031, Uttar Pradesh, India
[2] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA
来源：
JOURNAL OF MEDICAL MICROBIOLOGY | 2016年 / 65卷
关键词：
IN-VITRO ACTIVITY; CELL-WALL CORE; CAPURAMYCIN ANALOGS; CYSTIC-FIBROSIS; ABSCESSUS; TUBERCULOSIS; BENZOTHIAZINONES; TIGECYCLINE; RESISTANCE; CANDIDATE;
D O I：
10.1099/jmm.0.000198
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Non-tuberculous mycobacteria (NTM) infections are increasingly being reported worldwide. They are a major concern for healthcare professionals for multiple reasons, ranging from the intrinsic resistance of NTM to most conventionally utilized antimicrobials to inharmonious diagnostic criteria utilized for evaluation of NTM-infected patients, leading to high morbidity. In this review, we highlight the paucity of drugs having potent anti-NTM activity amongst the new antimicrobials currently under various stages of development for anti-tubercular activity and issue a call for the establishment of a concerted dedicated drug discovery pipeline targeting NTM.
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页码：1 / 8
页数：8
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