Affected sib-pair tests for linkage: Type I errors with dependent sib-pairs

被引：0

作者：

Meunier, F ^{[1
]}

Philippi, A ^{[1
]}

Martinez, M ^{[1
]}

Demenais, F ^{[1
]}

机构：

[1] Hop St Louis, INSERM, U358, F-75010 Paris, France

来源：

GENETIC EPIDEMIOLOGY | 1997年 / 14卷 / 06期

关键词：

dependence; linkage tests; missing data; sib-pairs; type-I-errors; weight;

D O I：

10.1002/(SICI)1098-2272(1997)14:6<1107::AID-GEPI91>3.0.CO;2-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We compared the robustness of affected-sib-pair (ASP) tests for multiple-affected sibships. Forming all possible pairs increases the type I errors only slightly whereas the most used weighting procedures decrease the efficiency of the tests. Another weighting procedure accounting for the reduction of variance of the weighted identical by descent (IBD) information appears robust. Missing parental marker data leads to a decrease of type I errors in all cases. (C) 1997 Wiley-Liss, Inc.

引用

页码：1107 / 1111

页数：5

共 10 条

[1] NONPARAMETRIC-TESTS FOR LINKAGE WITH DEPENDENT SIB PAIRS [J].