Postextinction infusion of a mitogen-activated protein kinase inhibitor into the medial prefrontal cortex impairs memory of the extinction of conditioned fear

被引:104
作者
Hugues, S [1 ]
Deschaux, O [1 ]
Garcia, R [1 ]
机构
[1] Univ Nice Sophia Antipolis, F-06108 Nice, France
关键词
D O I
10.1101/lm.77704
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We investigated whether postextinction training infusion of PD098059, a selective inhibitor of mitogen-activated protein kinase (MAPK) activation, into the medial prefrontal cortex, would impair retention of extinction learning in rats. We found that immediate, but not late (2 or 4 h), postextinction infusion of PD098059 provoked a full return of conditioned freezing. These results suggest that activation of prefrontal MAPK in early stages of postextinction training participates in processes that protect against spontaneous recovery of aversive responses.
引用
收藏
页码:540 / 543
页数:4
相关论文
共 20 条