Defect formation induced by PAMAM dendrimers on Pt-supported bilayer lipid membranes investigated by electrochemistry

被引：17

作者：

Huang, WM ^{[1
]}

Han, XJ ^{[1
]}

Wang, EK ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China

来源：

JOURNAL OF THE ELECTROCHEMICAL SOCIETY | 2003年 / 150卷 / 04期

关键词：

D O I：

10.1149/1.1554920

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

The interaction of polyamidoamine (PAMAM) dendrimers (generations 1-7) with supported bilayer lipid membranes was studied by cyclic votammetry and ac impedance. It is shown that the dendrimers (generations 4-6) can induce defects in the Pt-electrode-supported bilayer lipid membrane. The ability of dendrimers to induce defects was dependent on their shapes and surface charge. The results are consistent with a change in the morphology of the dendrimers from an open, branched structure for generations 1-4 to a closed, increasingly compact surface for generations 5-7. (C) 2003 The Electrochemical Society.

引用

页码：E218 / E221

页数：4

共 35 条

[1] Alahari SK, 1998, J PHARMACOL EXP THER, V286, P419
[2] BORONATED STARBURST DENDRIMER MONOCLONAL-ANTIBODY IMMUNOCONJUGATES - EVALUATION AS A POTENTIAL DELIVERY SYSTEM FOR NEUTRON-CAPTURE THERAPY
BARTH, RF
ADAMS, DM
SOLOWAY, AH
ALAM, F
DARBY, MV
[J]. BIOCONJUGATE CHEMISTRY, 1994, 5 (01) : 58 - 66
[3] BLANK M, 1994, BIOMEMBRANE ELECTROC, V235, P491
[4] Alternating current voltammetry studies of the effect of melittin on heterogeneous electron transfer across a hybrid bilayer membrane supported on a gold electrode
Brevnov, DA
Finklea, HO
[J]. LANGMUIR, 2000, 16 (14) : 5973 - 5979
[5] Cyclic voltammetry and ac impedance studies of Ca2+-induced ion channels on Pt-BLM
Diao, P
Jiang, DL
Cui, XL
Gu, DP
Tong, RT
Zhong, B
[J]. BIOELECTROCHEMISTRY AND BIOENERGETICS, 1998, 45 (02): : 173 - 179
[6] FUNCTIONAL POLYMERS AND DENDRIMERS - REACTIVITY, MOLECULAR ARCHITECTURE, AND INTERFACIAL ENERGY
FRECHET, JMJ
[J]. SCIENCE, 1994, 263 (5154) : 1710 - 1715
[7] Fabrication and photoelectric properties of self-assembled bilayer lipid membranes on conducting glass
Gao, H
Luo, GA
Feng, J
Ottova, AL
Tien, HT
[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2000, 59 (1-3) : 87 - 91
[8] Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments
Goncz, KK
Kunzelmann, K
Xu, ZD
Gruenert, DC
[J]. HUMAN MOLECULAR GENETICS, 1998, 7 (12) : 1913 - 1919
[9] Ion-channel sensing of ferricyanide anion based on a supported bilayer lipid membrane
Han, XJ
Wang, E
[J]. ANALYTICAL SCIENCES, 2001, 17 (10) : 1171 - 1174
[10] Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium
Hudde, T
Rayner, SA
Comer, RM
Weber, M
Isaacs, JD
Waldmann, H
Larkin, DPF
George, AJT
[J]. GENE THERAPY, 1999, 6 (05) : 939 - 943

← 1 2 3 4 →