Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines

被引：261

作者：

Nance, Kellie D. ^{[1
]}

Meier, Jordan L. ^{[1
]}

机构：

[1] NCI, Chem Biol Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA

来源：

ACS CENTRAL SCIENCE | 2021年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

MESSENGER-RNA STRUCTURE; ENHANCES TRANSLATION; PSEUDOURIDINE; EXPRESSION; IMMUNOGENICITY; URIDINE; TOLL-LIKE-RECEPTOR-7; RECOGNITION; POLYMERASE; PROTEINS;

D O I：

10.1021/acscentsci.1c00197

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history. A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase N1-methylpseudouridine (m1 Psi) to increase their effectiveness. In this Outlook, we summarize the development and function of m1 Psi in synthetic mRNAs. By demystifying how a novel element within these medicines works, we aim to foster understanding and highlight future opportunities for chemical innovation.

引用

页码：748 / 756

页数：9

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