Solitary fibrous tumors of the central nervous system: Clinicopathological and therapeutic considerations of 18 cases

被引:77
作者
Metellus, Philippe
Bouvier, Corinne
Guyotat, Jacques
Fuentes, Stephane
Jouvet, Anne
Vasiljevic, Alexandre
Giorgi, Roch
Dufour, Henry
Grisoli, Francois
Figarella-Branger, Dominique
机构
[1] Timone Hosp, Dept Neuropathol, Marseille, France
[2] Timone Hosp, Dept Neurosurg, Marseille, France
[3] Timone Hosp, Dept Biostat, Marseille, France
[4] CHU Lyon, Dept Neurosurg, Lyon, France
[5] CHU Lyon, Dept Neuropathol, Lyon, France
关键词
CD; 34; fibrous meningioma; Hemangiopericytoma; radiotherapy; solitary fibrous tumor;
D O I
10.1227/01.NEU.0000255418.93678.AD
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
OBJECTIVE:This is a retrospective study of 18 patients harboring a solitary fibrous tumor of the central nervous system. Therapeutic management and outcome were analyzed. METHODS: Between 1999 and 2004, 18 patients harboring central nervous system solitary fibrous tumors were surgically treated at our two institutions. There were nine men and nine women. The patient ages ranged from 33 to 75 years, with a median age of 56.1 years. The locations were spinal in six cases (33.3%), the posterior fossa in six cases (33.3%), supratentorial in four cases (22.2%), and orbital in two cases (11.2%). RESULTS: The median follow-up period was 45.3 months. Gross total resection was achieved in 10 cases (55.6%); tumor recurrence or progression occurred in nine cases (50%). Incomplete surgical resection was significantly associated with recurrence (P=0.018). On univariate analysis, extent of surgery was also associated with a longer progression-free survival (P=0.05). No statistically significant correlation can be found between histological features and recurrence. CONCLUSION: Prognosis of solitary fibrous tumors of the central nervous system remains unclear; consequently, careful and close monitoring of patients and long-term follow-up are mandatory. Radical surgical excision seems to be a significant and reliable prognosis factor, although pathological prognostic features must be defined. In other respects, the role of postoperative radiotherapy in atypical or incompletely resected solitary fibrous tumors of the central nervous system remains to be determined and, therefore, warrants larger series with longer follow-up periods.
引用
收藏
页码:715 / 722
页数:8
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