3D printing of pink bioceramic scaffolds for bone tumor tissue therapy

被引：26

作者：

Wang, Xin ^{[1
,2
]}

Zhai, Dong ^{[1
,2
]}

Yao, Xiaogang ^{[1
,2
]}

Wang, Yufeng ^{[1
,3
]}

Ma, Hongshi ^{[1
,2
]}

Yu, Xiaopeng ^{[1
,2
]}

Du, Lin ^{[1
,2
]}

Lin, Huixing ^{[1
,2
]}

Wu, Chengtie ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

[3] Nanjing Med Univ, Dept Orthopaed Surg, Inst Digital Med, Nanjing Hosp 1, Nanjing 210006, Jiangsu, Peoples R China

来源：

APPLIED MATERIALS TODAY | 2022年 / 27卷

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

Calcium titanate(CaTiO3); 3D printing; Pink bioceramic; Photothermal performance; Tumor-induced bone defect therapy; COMPOSITES;

D O I：

10.1016/j.apmt.2022.101443

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

For therapy of tumor-induced bone defects, functional biomaterials with tumor therapy and bone re-generation are of great importance. In this study, 3D printing of calcium titanate (CaTiO3) bioceramic scaffolds was prepared for the therapy of tumor-induced bone defects. The digital laser processing (DLP) based 3D printing technology was applied to prepared CaTiO3 & nbsp;bioceramic scaffolds. It was found that the color of CaTiO3 & nbsp;(CaTi) scaffolds was deeper with the sintering temperature rising. Interestingly, CaTi scaf-folds with pink color were found with optimal compressive strength (13.44 +/-& nbsp;0.99 MPa) and satisfactory photothermal property when exposed to NIR laser. The temperature of pink CaTi scaffolds could be over 70 ?& nbsp;under NIR laser irradiation (1.32 W/cm(2)). Attributing to such excellent photothermal performance, CaTi scaffolds had been used as a photothermal biomaterial for the effective therapy of the in vitro and in vivo bone tumor. Moreover, the prepared pink CaTi scaffolds possessed bone-forming in vitro and in vivo. Therefore, 3D printing of pink CaTi bioceramic scaffolds represents a promising strategy by using the bifunctional biomaterial for tumor-induced bone defect therapy. (C)& nbsp;2022 Elsevier Ltd. All rights reserved.

引用

页数：9

共 40 条

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