Biologic approaches to the prevention of sexual transmission of human immunodeficiency virus

被引:8
作者
Blocker, ME
Cohen, MS
机构
[1] Univ N Carolina, Div Infect Dis, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Ctr Infect Dis, Chapel Hill, NC 27599 USA
关键词
D O I
10.1016/S0891-5520(05)70143-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human immunodeficiency virus is a leading cause of morbidity and mortality worldwide. Currently, no curative therapy exists; therefore, prevention is the best method to control the epidemic. Sexual contact is the most common route of transmission of HIV. This article reviews several strategies for prevention of sexual transmission of HIV. It focuses on vaccine development, antiretroviral therapy, and microbicides.
引用
收藏
页码:983 / +
页数:18
相关论文
共 107 条
[71]   Cervical and vaginal shedding of human immunodeficiency virus type 1-infected cells throughout the menstrual cycle [J].
Mostad, SB ;
Jackson, S ;
Overbaugh, J ;
Reilly, M ;
Chohan, B ;
Mandaliya, K ;
Nyange, P ;
Ndinya-Achola, J ;
Bwayo, JJ ;
Kreiss, JK .
JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (04) :983-991
[72]   ANTIRETROVIRAL TREATMENT OF MEN INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REDUCES THE INCIDENCE OF HETEROSEXUAL TRANSMISSION [J].
MUSICCO, M ;
LAZZARIN, A ;
NICOLOSI, A ;
GASPARINI, M ;
COSTIGLIOLA, P ;
ARICI, C ;
SARACCO, A .
ARCHIVES OF INTERNAL MEDICINE, 1994, 154 (17) :1971-1976
[73]   High rates of transmission of subtype E human immunodeficiency virus type 1 among heterosexual couples in northern Thailand: Role of sexually transmitted diseases and immune compromise [J].
Nelson, KE ;
Rungruengthanakit, K ;
Margolick, J ;
Suriyanon, V ;
Niyomthai, S ;
de Boer, MA ;
Kawichai, S ;
Robison, V ;
Celentano, DD ;
Nagachinta, T ;
Duerr, A .
JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (02) :337-343
[74]   Changes in sexual behavior and a decline in HIV infection among young men in Thailand [J].
Nelson, KE ;
Celentano, DD ;
Eiumtrakol, S ;
Hoover, DR ;
Beyrer, C ;
Suprasert, S ;
Kuntolbutra, S ;
Khamboonruang, C .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (05) :297-303
[75]   Repertoire of chemokine receptor expression in the female genital tract - Implications for human immunodeficiency virus transmission [J].
Patterson, BK ;
Landay, A ;
Andersson, J ;
Brown, C ;
Behbahani, H ;
Jiyamapa, D ;
Burki, Z ;
Stanislawski, D ;
Czerniewski, MA ;
Garcia, P .
AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (02) :481-490
[76]   Characterization of V3 sequence heterogeneity in subtype C human immunodeficiency virus type 1 isolates from Malawi: Underrepresentation of X4 variants [J].
Ping, LH ;
Nelson, JAE ;
Hoffman, IF ;
Schock, J ;
Lamers, SL ;
Goodman, M ;
Vernazza, P ;
Kazembe, P ;
Maida, M ;
Zimba, D ;
Goodenow, MM ;
Eron, JJ ;
Fiscus, SA ;
Cohen, MS ;
Swanstrom, R .
JOURNAL OF VIROLOGY, 1999, 73 (08) :6271-6281
[77]  
PING LH, IN PRESS J VIROL
[78]   Human immunodeficiency virus type 1 strains of subtypes B and E replicate in cutaneous dendritic cell T-cell mixtures without displaying subtype-specific tropism [J].
Pope, M ;
Frankel, SS ;
Mascola, JR ;
Trkola, A ;
Isdell, F ;
Birx, DL ;
Burke, DS ;
Ho, DD ;
Moore, JP .
JOURNAL OF VIROLOGY, 1997, 71 (10) :8001-8007
[79]   Viral load and heterosexual transmission of human immunodeficiency virus type 1 [J].
Quinn, TC ;
Wawer, MJ ;
Sewankambo, N ;
Serwadda, D ;
Li, CJ ;
Wabwire-Mangen, F ;
Meehan, MO ;
Lutalo, T ;
Gray, RH .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (13) :921-929
[80]   A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases [J].
Roddy, RE ;
Zekeng, L ;
Ryan, KA ;
Tamoufé, U ;
Weir, SS ;
Wong, EL .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (08) :504-510