Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'?

被引:43
作者
Langan, E. A. [1 ]
Nie, Z. [1 ]
Rhodes, L. E. [1 ]
机构
[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Salford Royal NHS Fdn Trust, Epithelial Sci Res Grp,Photobiol Unit, Manchester, Lancs, England
关键词
alpha-melanocyte stimulating hormone analogues; melanotan; moles; photoprotection; photosensitivity disorders; tanning; MELANOCYTE-STIMULATING HORMONE; POLYMORPHIC LIGHT ERUPTION; INDUCED DNA-DAMAGE; QUALITY-OF-LIFE; ERYTHROPOIETIC PROTOPORPHYRIA; MELANOGENESIS; HUMANS; SKIN; PHOTOSENSITIVITY; VOLUNTEERS;
D O I
10.1111/j.1365-2133.2010.09891.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
P>While ultraviolet radiation (UVR) is a major cause of skin ageing and carcinogenesis, public pursuit of a novel tanning strategy circumventing the need for UVR is increasingly reported in the media and scientific press. This involves the subcutaneous self-administration of unregulated products labelled as melanotan I and/or II, synthetic analogues of alpha-melanocyte stimulating hormone (alpha-MSH), as obtained via the internet, tanning salons and gyms. The Medicines and Healthcare products Regulatory Authority has recently raised awareness of the public health risk of transmission of blood-borne viruses from the needle sharing that may occur, and of the potential impurity of these products. Dermatologists should also be aware that these agents can complicate the clinical presentation of patients with pigmented lesions; their use may be suspected in unexpectedly tanned individuals with rapidly pigmenting naevi. Meanwhile, the regulated alpha-MSH analogue afamelanotide (Clinuvel Pharmaceuticals Ltd, Melbourne, Australia) is showing promise for its photoprotective potential, and is undergoing phase II and III clinical trials in people with photosensitivity disorders and those prone to nonmelanoma skin cancer. The photoprotective and other biological effects of alpha-MSH analogues await full determination.
引用
收藏
页码:451 / 455
页数:5
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