Glutathione: new roles in redox signaling for an old antioxidant

被引:638
作者
Aquilano, Katia [1 ]
Baldelli, Sara [2 ]
Ciriolo, Maria R. [1 ]
机构
[1] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy
[2] Univ Telemat San Raffaele Roma, Sci Inst Res Hospitalizat & Hlth Care, Rome, Italy
来源
FRONTIERS IN PHARMACOLOGY | 2014年 / 5卷
关键词
nitric oxide; viral infection; autophagy; redox signal; reactive oxygen species; MITOCHONDRIAL RESPIRATORY-CHAIN; NF-KAPPA-B; NITRIC-OXIDE; S-NITROSOGLUTATHIONE; OXIDATIVE STRESS; REACTIVE OXYGEN; INTRACELLULAR GLUTATHIONE; DNA-BINDING; SUPEROXIDE-DISMUTASE; NEUROBLASTOMA-CELLS;
D O I
10.3389/fphar.2014.00196
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.
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页数:12
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共 137 条
  • [1] Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses
    Abdalla, MY
    Ahmad, IM
    Spitz, DR
    Schmidt, WN
    Britigan, BE
    [J]. JOURNAL OF MEDICAL VIROLOGY, 2005, 76 (04) : 489 - 497
  • [2] Redox-Based Regulation of Apoptosis: S-Glutathionylation As a Regulatory Mechanism to Control Cell Death
    Anathy, Vikas
    Roberson, Elle C.
    Guala, Amy S.
    Godburn, Karolyn E.
    Budd, Ralph C.
    Janssen-Heininger, Yvonne M. W.
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2012, 16 (06) : 496 - 505
  • [3] Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease
    Anckar, Julius
    Sistonen, Lea
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80, 2011, 80 : 1089 - 1115
  • [4] TRANSPORT AND DIRECT UTILIZATION OF GAMMA-GLUTAMYLCYST(E)INE FOR GLUTATHIONE SYNTHESIS
    ANDERSON, ME
    MEISTER, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (03): : 707 - 711
  • [5] Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1
    Aquilano, Katia
    Vigilanza, Paola
    Rotilio, Giuseppe
    Ciriolo, Maria Rosa
    [J]. FASEB JOURNAL, 2006, 20 (10) : 1683 - +
  • [6] p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance
    Aquilano, Katia
    Baldelli, Sara
    Pagliei, Beatrice
    Cannata, Stefano M.
    Rotilio, Giuseppe
    Ciriolo, Maria R.
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2013, 18 (04) : 386 - 399
  • [7] Aquilano Katia, 2011, Commun Integr Biol, V4, P477, DOI 10.4161/cib.4.4.15654
  • [8] Nitric oxide is the primary mediator of cytotoxicity induced by GSH depletion in neuronal cells
    Aquilano, Katia
    Baldelli, Sara
    Cardaci, Simone
    Rotilio, Giuseppe
    Ciriolo, Maria Rosa
    [J]. JOURNAL OF CELL SCIENCE, 2011, 124 (07) : 1043 - 1054
  • [9] Tau dephosphorylation and microfilaments disruption are upstream events of the anti-proliferative effects of DADS in SH-SY5Y cells
    Aquilano, Katia
    Vigilanza, Paola
    Filomeni, Giuseppe
    Rotilio, Giuseppe
    Ciriolo, Maria R.
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2010, 14 (03) : 564 - 577
  • [10] Atakisi O, 2010, EUR REV MED PHARMACO, V14, P19