Interleukin 17 (IL-17) and interleukin 23 (IL-23) levels are modulated by compressive orthodontic forces in humans

被引:5
作者
Allgayer, Susiane [1 ]
de Menezes, Luciane Macedo [2 ]
Batista, Eraldo L., Jr. [3 ]
机构
[1] Assoc Brasileira Odontol ABORS, Dept Orthodont, Rua Furriel Luis de Vargas 134, BR-90619900 Porto Alegre, RS, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul PUCRS, Dept Orthodont, Ave Ipiranga 6681, BR-90619900 Porto Alegre, RS, Brazil
[3] Univ Manitoba, Coll Dent, Fac Hlth Sci, Dept Diagnost & Surg Sci,Div Periodont,Dept Oral, Winnipeg, MB R3E 0W2, Canada
关键词
Biologic marker; Interleukin; Interleukin-17; Maxillary expansion; Orthodontic appliances; Th17; cells; GINGIVAL CREVICULAR FLUID; PERIODONTAL-LIGAMENT; TOOTH MOVEMENT; CELL-DIFFERENTIATION; ROOT RESORPTION; TH17; CELLS; EXPRESSION; CYTOKINES; KINETICS; SITES;
D O I
10.1016/j.ejwf.2019.06.001
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objective: The purpose of the investigation was to evaluate whether the application of compression forces exerted on the periodontal ligament during orthodontic movement is reflected at the level of interleukin (IL)-17 and IL-23. Materials and methods: The gingival crevicular fluid (GCF) samples from the compression sites of 32 molars from 16 patients prescribed with modified Hyrax appliance were collected. The GCF were analyzed for IL-17, IL-23, and IL-1 beta (Control) at baseline and at 1, 7, and 14 days of active wear of the appliance. Results: Orthodontic forces resulted in increased levels of IL-17 and IL-23 in the GCF, which were statistically significant at 7 days of force application at compression sites. At day 14, levels decreased to baseline; IL-1 beta levels (positive control) were more elevated at all times after force application. IL-17 and IL-23 levels were significantly lower than IL-1D, and undetectable in some samples. Conclusion: Upregulation of IL-17 and IL-23 occurred in response to the force application in compression sites. Monitoring the levels of inflammatory mediators might be a clinically useful procedure, as they may help to define optimal forces to produce the most rapid tooth movement. (C) 2019 World Federation of Orthodontists.
引用
收藏
页码:148 / 152
页数:5
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