The anticonvulsant zonisamide scavenges free radicals

被引：107
作者：
Mori, A [1 ]
Noda, Y [1 ]
Packer, L [1 ]
机构：
[1] Univ Calif Berkeley, Dept Cell & Mol Biol, Berkeley, CA 94720 USA
来源：
EPILEPSY RESEARCH | 1998年 / 30卷 / 02期
关键词：
zonisamide; antiepileptics; free radicals; hydroxyl radical; nitric oxide; electron spin resonance;
D O I：
10.1016/S0920-1211(97)00097-1
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Zonisamide (ZNS) is effective in animal models of epilepsy and epileptic patients. The free radical scavenging activities of ZNS were analyzed by using electron spin resonance. ZNS, in the mmolar range, scavenged hydroxyl and nitric oxide radicals in a dose-dependent manner. This suggests that the mechanism of antiepileptic effect of ZNS may involve protection of neurons from free radical damage and stabilization of neuronal membranes. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：153 / 158
页数：6
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