Speckle-Tracking Echocardiography for Detecting Subclinical Left Ventricular Dysfunction in Patients With Familial Hypercholesterolemia

被引:3
作者
Li, Rongjuan [1 ,2 ]
Xie, Jinjie [1 ,2 ]
Jiang, Bo [3 ]
Sun, Zhonghua [4 ]
Wang, Lvya [5 ]
Leng, Zhaoting [1 ,2 ]
Wang, Yueli [1 ,2 ]
Yang, Ya [1 ,2 ,6 ]
机构
[1] Capital Med Univ, Beijing Anzhen Hosp, Dept Echocardiog, Beijing 100029, Peoples R China
[2] Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, Beijing, Peoples R China
[4] Curtin Univ, Discipline Med Radiat Sci, Perth, WA, Australia
[5] Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Key Lab Remodeling Related Cardiovasc Dis, Beijing Anzhen Hosp,Minist Educ, Beijing, Peoples R China
[6] Natl Clin Res Ctr Cardiovasc Dis, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Cholesterol; LDL; echocardiography; Doppler; elasticity imaging techniques/methods; heart/diagnostic imaging; hypercholesterolemia; hyperlipoproteinemia type II; myocardial ischemia; ventricular dysfunctionl; left; MYOCARDIAL DEFORMATION; INFARCT SIZE; YOUNG-ADULTS; ATHEROSCLEROSIS; ASSOCIATION; CHILDREN; GUIDANCE; PANEL; PREDICTION; MANAGEMENT;
D O I
10.14503/THIJ-18-6720
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myocardial ischemia and left ventricular dysfunction have been documented in young adults with familial hypercholesterolemia. We investigated whether speckle-tracking echocardiography can be used to detect subclinically impaired global and regional myocardial function in patients with this lipid disorder. This single-center study included 47 patients with familial hypercholesterolemia and 37 healthy control subjects who underwent transthoracic Doppler echocardiography and speckle-tracking echocardiography from January 2003 through December 2016. Conventional echocardiographic and strain parameters in the 2 groups were analyzed and compared. Left ventricular dimensions were significantly larger at end-diastole (P=0.02) and endsystole (P=0.013), left ventricular walls were significantly thicker (P < 0.0001), and the early transmitral/early diastolic mitral annular velocity ratio was significantly higher (P=0.006) in the patient group than in the control group. In the patient group, global longitudinal and circumferential strain values were significantly lower (P < 0.0001) and global radial strain values significantly higher (P=0.006); all segmental longitudinal strain (P <0.04) and most segmental circumferential strain values (P <= 0.01) were significantly lower; and some segmental radial strains, especially at the apex, were significantly higher (P <= 0.04). However, average longitudinal, circumferential, and radial strains in the different segments of the 3 main coronary artery territories were significantly lower in the patient group (P < 0.01). Global longitudinal strain (r=0.561; P=0.001) and global circumferential strain (r=0.565; P < 0.0001) were inversely correlated with low-density-lipoprotein cholesterol levels. We conclude that speckle-tracking echocardiography can be used to detect subclinical global and regional systolic abnormalities in patients with familial hypercholesterolemia.
引用
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页数:9
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共 32 条
[1]   Myocardial Deformation Imaging by Two-Dimensional Speckle-Tracking Echocardiography for Prediction of Global and Segmental Functional Changes after Acute Myocardial Infarction: A Comparison with Late Gadolinium Enhancement Cardiac Magnetic Resonance [J].
Altiok, Ertunc ;
Tiemann, Sonja ;
Becker, Michael ;
Koos, Ralf ;
Zwicker, Christian ;
Schroeder, Joerg ;
Kraemer, Nils ;
Schoth, Felix ;
Adam, Dan ;
Friedman, Zvi ;
Marx, Nikolaus ;
Hoffmann, Rainer .
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2014, 27 (03) :249-257
[2]  
Benn M, J CLIN ENDOCR METAB, V99
[3]   Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment [J].
Borlaug, Barry A. ;
Paulus, Walter J. .
EUROPEAN HEART JOURNAL, 2011, 32 (06) :670-+
[4]   NONINVASIVE DETECTION OF ENDOTHELIAL DYSFUNCTION IN CHILDREN AND ADULTS AT RISK OF ATHEROSCLEROSIS [J].
CELERMAJER, DS ;
SORENSEN, KE ;
GOOCH, VM ;
SPIEGELHALTER, DJ ;
MILLER, OI ;
SULLIVAN, ID ;
LLOYD, JK ;
DEANFIELD, JE .
LANCET, 1992, 340 (8828) :1111-1115
[5]   Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society [J].
Cuchel, Marina ;
Bruckert, Eric ;
Ginsberg, Henry N. ;
Raal, Frederick J. ;
Santos, Raul D. ;
Hegele, Robert A. ;
Kuivenhoven, Jan Albert ;
Nordestgaard, Borge G. ;
Descamps, Olivier S. ;
Steinhagen-Thiessen, Elisabeth ;
Tybjrg-Hansen, Anne ;
Watts, Gerald F. ;
Averna, Maurizio ;
Boileau, Catherine ;
Boren, Jan ;
Catapano, Alberico L. ;
Defesche, Joep C. ;
Hovingh, G. Kees ;
Humphries, Steve E. ;
Kovanen, Petri T. ;
Masana, Luis ;
Pajukanta, Paivi ;
Parhofer, Klaus G. ;
Ray, Kausik K. ;
Stalenhoef, Anton F. H. ;
Stroes, Erik ;
Taskinen, Marja-Riitta ;
Wiegman, Albert ;
Wiklund, Olov ;
Chapman, M. John .
EUROPEAN HEART JOURNAL, 2014, 35 (32) :2146-U100
[6]   Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization [J].
Descamps, O. S. ;
Tenoutasse, S. ;
Stephenne, X. ;
Gies, I. ;
Beauloye, V. ;
Lebrethon, M. -C. ;
De Beaufort, C. ;
De Waele, K. ;
Scheen, A. ;
Rietzschel, E. ;
Mangano, A. ;
Panier, J. P. ;
Ducobu, J. ;
Langlois, M. ;
Balligand, J. -L. ;
Legat, P. ;
Blaton, V. ;
Muls, E. ;
Van Gaal, L. ;
Sokal, E. ;
Rooman, R. ;
Carpentier, Y. ;
De Backer, G. ;
Heller, F. R. .
ATHEROSCLEROSIS, 2011, 218 (02) :272-280
[7]   Early Left Ventricular Abnormalities in Children with Heterozygous Familial Hypercholesterolemia [J].
Di Salvo, Giovanni ;
D'Aiello, Angelo Fabio ;
Castaldi, Biagio ;
Fadel, Bahaa ;
Limongelli, Giuseppe ;
D'Andrea, Antonello ;
Pergola, Valeria ;
Pacileo, Giuseppe ;
Del Giudice, Emanuele Miraglia ;
Perrone, Laura ;
Calabro, Raffaele ;
Russo, Maria Giovanna .
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2012, 25 (10) :1075-1082
[8]   Prediction of infarct size using two-dimensional speckle tracking echocardiography in acute myocardial infarction [J].
Dogan, Cem ;
Bayram, Zubeyde ;
Candan, Ozkan ;
Omaygenc, Onur ;
Yilmaz, Fatih ;
Acar, Rezzan Deniz ;
Akbal, Ozgur Yasar ;
Kaymaz, Cihangir ;
Ozdemir, Nihal .
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 2017, 34 (03) :376-382
[9]   Global longitudinal strain measured by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease [J].
Gjesdal, Ola ;
Hopp, Einar ;
Vartdal, Trond ;
Lunde, Ketil ;
Helle-Valle, Thomas ;
Aakhus, Svend ;
Smith, Hans-Jorgen ;
Ihlen, Hallfdan ;
Edvardsen, Thor .
CLINICAL SCIENCE, 2007, 113 (5-6) :287-296
[10]   Familial Hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients Clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia [J].
Goldberg, Anne C. ;
Hopkins, Paul N. ;
Toth, Peter P. ;
Ballantyne, Christie M. ;
Rader, Daniel J. ;
Robinson, Jennifer G. ;
Daniels, Stephen R. ;
Gidding, Samuel S. ;
de Ferranti, Sarah D. ;
Ito, Matthew K. ;
McGowan, Mary P. ;
Moriarty, Patrick M. ;
Cromwell, William C. ;
Ross, Joyce L. ;
Ziajka, Paul E. .
JOURNAL OF CLINICAL LIPIDOLOGY, 2011, 5 (03) :S1-S8