Pyrimidine: a review on anticancer activity with key emphasis on SAR

被引：99
作者：
Mahapatra, Aastha [1 ]
Prasad, Tanya [1 ]
Sharma, Tripti [1 ]
机构：
[1] Siksha O Anusandhan, Fac Pharmaceut Sci, Dept Med Chem, Bhubaneswar 751003, Odisha, India
来源：
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES | 2021年 / 7卷 / 01期
关键词：
Pyrimidine; Anticancer activity; Structure activity relationship; Heterocyclic compounds; APOPTOSIS-INDUCING ABILITY; VITRO ANTITUMOR EVALUATION; CYCLIN-DEPENDENT KINASES; ANTI-BREAST CANCER; BIOLOGICAL EVALUATION; IN-VITRO; DERIVATIVES BEARING; POTENT ANTITUMOR; ANTIPROLIFERATIVE ACTIVITY; TYROSINE KINASE;
D O I：
10.1186/s43094-021-00274-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents. Pyrimidine, a privileged scaffold, is part of living organisms and plays vital role in various biological procedures as well as in cancer pathogenesis. Due to resemblance in structure with the nucleotide base pair of DNA and RNA, it is recognized as valuable compound in the treatment of cancer. Main text Many novel pyrimidine derivatives have been designed and developed for their anticancer activity in the last few years. The present review aims to focus on the structure activity relationship (SAR) of pyrimidine derivatives as anticancer agent from the last decade. Conclusion This review intends to assist in the development of more potent and efficacious anticancer drugs with pyrimidine scaffold.
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页数：38
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共 148 条
[1]   Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives [J].
Abbas, Safinaz E. ;
Gawad, Nagwa M. Abdel ;
George, Riham F. ;
Akar, Yahya A. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 65 :195-204
[2]   Synthesis of novel pyrazolo[3,4-d]pyrimidine derivatives as potential anti-breast cancer agents [J].
Abd El Hamid, Mohammed K. ;
Mihovilovic, Marko D. ;
El-Nassan, Hala B. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 57 :323-328
[3]  
Abdel-Latif E., 2016, EGYPTIAN J BASIC APP, V3, P118, DOI [10.1016/j.ejbas.2015.11.001, DOI 10.1016/J.EJBAS.2015.11.001]
[4]   New 2,4-disubstituted-2-thiopyrimidines as VEGFR-2 inhibitors: Design, synthesis, and biological evaluation [J].
Abdel-Mohsen, Heba T. ;
Girgis, Adel S. ;
Mahmoud, Abeer E. E. ;
Ali, Mamdouh M. ;
El Diwani, Hoda, I .
ARCHIV DER PHARMAZIE, 2019, 352 (11)
[5]   Design, synthesis and antitumor activity of novel pyrazolo[3,4-d]pyrimidine derivatives as EGFR-TK inhibitors [J].
Abdelgawad, Mohamed A. ;
Bakr, Rania B. ;
Alkhoja, Olla A. ;
Mohamed, Wafaa R. .
BIOORGANIC CHEMISTRY, 2016, 66 :88-96
[6]  
AbdEllatif M., 2018, J HETEROCYCLE CHEM, V55, P419, DOI [10.1002/jhet.3058, DOI 10.1002/JHET.3058]
[7]   Synthesis and anticancer activity of new quinazoline derivatives [J].
Abuelizz, Hatem A. ;
Marzouk, Mohamed ;
Ghabbour, Hazem ;
Al-Salahi, Rashad .
SAUDI PHARMACEUTICAL JOURNAL, 2017, 25 (07) :1047-1054
[8]   Synthesis and anticancer activity evaluation of novel azacalix[2]arene[2]pyrimidines [J].
Addepalli, Yesu ;
Yang, Xiaohong ;
Zhou, Minghui ;
Reddy, D. Prabhakar ;
Zhang, Shao-Lin ;
Wang, Zhen ;
He, Yun .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 151 :214-225
[9]   Synthesis and antiproliferative activity of imidazo[1,2-a]pyrimidine Mannich bases [J].
Aeluri, Raghunath ;
Alla, Manjula ;
Polepalli, Sowjanya ;
Jain, Nishant .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 100 :18-23
[10]   Design, synthesis, molecular modeling and anti-breast cancer activity of novel quinazolin-4-one derivatives linked to thiazolidinone, oxadiazole or pyrazole moieties [J].
Ahmed, Marwa F. ;
Belal, Amany ;
Youns, Mahmoud .
MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (07) :2993-3007
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