Impact of pneumococcal vaccination in children on serotype distribution in adult community-acquired pneumonia using the serotype-specific multiplex urinary antigen detection assay

被引：30
作者：
Pletz, Mathias W. [1 ,2 ]
Ewig, Santiago [2 ,3 ,4 ]
Rohde, Gernot [2 ,5 ,6 ]
Schuette, Hartwig [2 ,7 ]
Rupp, Jan [2 ,8 ]
Welte, Tobias [2 ,6 ,9 ]
Suttorp, Norbert [2 ,7 ]
Forstner, Christina [1 ,10 ]
机构：
[1] Jena Univ Hosp, Ctr Infect Dis & Infect Control, Erlanger Allee 101, D-07747 Jena, Germany
[2] CAPNETZ STIFTUNG, Carl Neuberg Str 1, D-30625 Hannover, Germany
[3] Evangel Hosp Herne, Dept Resp Med & Infect Dis, Thorax Ctr Ruhr Area, Bergstr 26, D-44791 Bochum, Germany
[4] Augusta Hosp Bochum, Bergstr 26, D-44791 Bochum, Germany
[5] Maastricht Univ Med Ctr, Dept Resp Med, P Debyelaan 25, NL-6202 AZ Maastricht, Netherlands
[6] German Ctr Lung Res DZL, Biomed Res Endstage & Obstruct Lung Dis Hannover, Carl Neuberg Str 1, D-30625 Hannover, Germany
[7] Charite, Dept Internal Med Infect Dis & Pulm Med, Augustenburger Pl 1, D-13353 Berlin, Germany
[8] Med Univ Lubeck, Dept Infect Dis & Microbiol, Ratzeburger Allee 160, D-23538 Lubeck, Germany
[9] Hannover Med Sch, Dept Pulm Med, Carl Neuberg Str 1, D-30625 Hannover, Germany
[10] Med Univ Vienna, Div Infect Dis & Trop Med, Dept Med 1, Wahringer Gurtel 18-20, A-1090 Vienna, Austria
来源：
VACCINE | 2016年 / 34卷 / 20期
关键词：
Pneumococcal vaccination; Conjugate vaccines; Pneumococcal pneumonia; CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; COMPETENCE NETWORK; DISEASE; OUTCOMES; CAPNETZ;
D O I：
10.1016/j.vaccine.2016.03.052
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aim of the study was to compare the distribution of the vaccine-serotypes covered by pneumococcal conjugate vaccines (PCV7 and PCV13) in adult patients with pneumococcal community-acquired pneumonia in Germany between the periods 2002-2006 and 2007-2011 using a novel serotype-specific multiplex urinary antigen detection assay (SSUA). Vaccination of children started with PCV7 in 2007, which was replaced by PCV13 in 2010. Following confirmation of the accuracy of SSUA in long-term stored urine samples from 112 patients with confirmed pneumonia and known pneumococcal serotype, urine samples of 391 CAPNETZ patients with documented pneumococcal pneumonia (i.e. positive BinaxNOW (R) Streptococcus pneumoniae urine antigen test) but unknown serotype were tested for the 13 vaccine-serotypes using SSUA. The proportion of PCV7-serotypes significantly decreased in adult patients with pneumonia from 30.6% (2002-6) to 13.3% (2007-11, p < 0.001); in bacteremic pneumonia, PCV7-serotypes completely disappeared (3/14 versus 0/19, p = 0.058). Conversely, pneumococcal serotypes included by PCV13 remained stable during study period with a coverage of 61.5% (2002-06) and 59.7% (2007-11) in non-bacteremic pneumonia and 79% (for both periods) in bacteremic pneumonia, mainly due to an increase in pneumococcal serotypes 1, 3 and 7F during the second period. Thus, implementation of PCV7 in children in Germany in 2007 was associated with a significant decrease in vaccine-serotypes covered by PCV7 in adult patients with non-bacteremic pneumococcal pneumonia and with an elimination of PCV7 vaccine-serotypes in bacteremic pneumococcal pneumonia. PCV13 coverage remained high up to 2011, mainly due to an increase in serotypes 1, 3 and 7F. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2342 / 2348
页数：7
相关论文
共 29 条
[1]  
[Anonymous], 2015, EPIDEMIOL B
[2]   Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination? [J].
Azzari, Chiara ;
Cortimiglia, Martina ;
Nieddu, Francesco ;
Moriondo, Maria ;
Indolfi, Giuseppe ;
Mattei, Romano ;
Zuliani, Massimo ;
Adriani, Beatrice ;
Degl'Innocenti, Roberto ;
Consales, Guglielmo ;
Aquilini, Donatella ;
Bini, Giancarlo ;
Di Natale, Massimo Edoardo ;
Canessa, Clementina ;
Ricci, Silvia ;
de Vitis, Elisa ;
Mangone, Giusi ;
Bechini, Angela ;
Bonanni, Paolo ;
Pasinato, Angela ;
Resti, Massimo .
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2016, 12 (02) :344-350
[3]   Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults [J].
Bonten, M. J. M. ;
Huijts, S. M. ;
Bolkenbaas, M. ;
Webber, C. ;
Patterson, S. ;
Gault, S. ;
van Werkhoven, C. H. ;
van Deursen, A. M. M. ;
Sanders, E. A. M. ;
Verheij, T. J. M. ;
Patton, M. ;
McDonough, A. ;
Moradoghli-Haftvani, A. ;
Smith, H. ;
Mellelieu, T. ;
Pride, M. W. ;
Crowther, G. ;
Schmoele-Thoma, B. ;
Scott, D. A. ;
Jansen, K. U. ;
Lobatto, R. ;
Oosterman, B. ;
Visser, N. ;
Caspers, E. ;
Smorenburg, A. ;
Emini, E. A. ;
Gruber, W. C. ;
Grobbee, D. E. .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (12) :1114-1125
[4]   The presence of pneumococcal bacteremia does not influence clinical outcomes in patients with community-acquired pneumonia -: Results from the Community-Acquired Pneumonia Organization (CAPO) International Cohort Study [J].
Bordon, Jose ;
Peyrani, Paula ;
Brock, Guy N. ;
Blasi, Francesco ;
Rello, Jordi ;
File, Thomas ;
Ramirez, Julio .
CHEST, 2008, 133 (03) :618-624
[5]   Clinical presentation, processes and outcomes of care for patients with pneumococcal pneumonia [J].
Brandenburg, JA ;
Marrie, TJ ;
Coley, CM ;
Singer, DE ;
Obrosky, DS ;
Kapoor, WN ;
Fine, MJ .
JOURNAL OF GENERAL INTERNAL MEDICINE, 2000, 15 (09) :638-646
[6]   Pneumococcal pneumonia: differences according to blood culture results [J].
Capelastegui, Alberto ;
Zalacain, Rafael ;
Bilbao, Amaia ;
Egurrola, Mikel ;
Ruiz Iturriaga, Luis Alberto ;
Quintana, Jose M. ;
Gomez, Ainhoa ;
Esteban, Cristobal ;
Espana, Pedro P. .
BMC PULMONARY MEDICINE, 2014, 14
[7]  
Feldman Charles, 2014, F1000Prime Rep, V6, P82, DOI 10.12703/P6-82
[8]  
Galanis I, 2016, EUR RESP J
[9]   Impact of 13-Valent Pneumococcal Conjugate Vaccination in Invasive Pneumococcal Disease Incidence and Mortality [J].
Harboe, Zitta Barrella ;
Dalby, Tine ;
Weinberger, Daniel M. ;
Benfield, Thomas ;
Molbak, Kare ;
Slotved, Hans Christian ;
Suppli, Camilla H. ;
Konradsen, Helle Bossen ;
Valentiner-Branth, Palle .
CLINICAL INFECTIOUS DISEASES, 2014, 59 (08) :1066-1073
[10]   A comparative study of bacteremic and non-bacteremic pneumococcal pneumonia [J].
Jover, Francisco ;
Cuadrado, Jose-Maria ;
Andreu, Lucio ;
Martinez, Silvia ;
Canizares, Ruth ;
de la Tabla, Victoria Ortiz ;
Martin, Coral ;
Roig, Pablo ;
Merino, Jaime .
EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2008, 19 (01) :15-21
123