A Novel Synthesis of Macitentan, an Endothelin Receptor Antagonist

被引：3
|
作者：
Nami, Majid [1 ]
Sovari, Sara Nasiri [2 ]
Haghighatnia, Yaghoub [2 ]
Dabiri, Minoo [1 ]
Salehi, Peyman [3 ]
机构：
[1] Shahid Beheshti Univ, Fac Chem, Tehran 1983963113, Iran
[2] Hasti Aria Shimi Co, Dept Res & Dev, Tehran 1463745481, Iran
[3] Shahid Beheshti Univ, Dept Phytochem, Med Plants & Drugs Res Inst, GC Evin, Tehran 1983963113, Iran
来源：
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL | 2017年 / 49卷 / 03期
关键词：
PULMONARY ARTERIAL-HYPERTENSION; THERAPY; SITAXSENTAN; BOSENTAN;
D O I：
10.1080/00304948.2017.1320921
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：258 / 264
页数：7
相关论文
共 50 条
  • [21] The new endothelin receptor antagonist macitentan: Prospects for therapy of pulmonary arterial hypertension
    Avdeev, S. N.
    TERAPEVTICHESKII ARKHIV, 2016, 88 (07) : 89 - 97
  • [22] A Novel Endothelin Receptor Antagonist, Macitentan Markedly Improved Severe Pulmonary Arterial Hypertension in Rats by a Nearly Complete Blockade of Endothelin Receptors
    Kunita, Mutsumi
    Kunita, Mutsumi
    CIRCULATION, 2013, 128 (22)
  • [23] OTEROMYCIN - A NOVEL ANTAGONIST OF ENDOTHELIN RECEPTOR
    SINGH, SB
    GOETZ, MA
    JONES, ET
    BILLS, GF
    GIACOBBE, RA
    HERRANZ, L
    STEVENSMILES, S
    WILLIAMS, DL
    JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (21): : 7040 - 7042
  • [24] Separation and Characterization of New Forced Degradation Products of Macitentan: A Dual Endothelin Receptor Antagonist
    Thummar, Mohit
    Swain, Debasish
    Gananadhamu, S.
    CHROMATOGRAPHIA, 2018, 81 (03) : 525 - 531
  • [25] RADIOSENSITIZING EFFECTS OF THE PAN ENDOTHELIN RECEPTOR ANTAGONIST, MACITENTAN, IN PRECLINICAL MODELS OF PROSTATE CANCER
    Festuccia, Claudio
    Gravina, Giovanni Luca
    D'Ascenzo, Sandra
    Dolo, Vincenza
    Ricevuto, Enrico
    Tombolini, Vincenzo
    ANTICANCER RESEARCH, 2010, 30 (04) : 1420 - 1421
  • [26] Asymmetric synthesis of an endothelin receptor antagonist
    Devine, PN
    Desmond, R
    Frey, LF
    Heid, RM
    Song, ZG
    Tillyer, RD
    Tschaen, DM
    Zhao, MZ
    Kato, Y
    Mano, E
    Okada, S
    Kato, S
    Mase, T
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1999, 57 (11) : 1016 - 1025
  • [27] The potential for macitentan, a new dual endothelin receptor antagonist, in the treatment of pulmonary arterial hypertension
    Steriade, Alexandru
    Seferian, Andrei
    Jais, Xavier
    Savale, Laurent
    Jutant, Etienne-Marie
    Parent, Florence
    Sitbon, Olivier
    Humbert, Marc
    Simonneau, Gerald
    Montani, David
    THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, 2014, 8 (03) : 84 - 92
  • [28] Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist
    Iglarz, Marc
    Binkert, Christoph
    Morrison, Keith
    Fischli, Walter
    Gatfield, John
    Treiber, Alexander
    Weller, Thomas
    Bolli, Martin H.
    Boss, Christoph
    Buchmann, Stephan
    Capeleto, Bruno
    Hess, Patrick
    Qiu, Changbin
    Clozel, Martine
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 327 (03): : 736 - 745
  • [29] Comparison of the dissolution and pharmacokinetic profiles of two galenical formulations of the endothelin receptor antagonist macitentan
    Kummer, Oliver
    Haschke, Manuel
    Hammann, Felix
    Bodmer, Michael
    Bruderer, Shirin
    Regnault, Yann
    Dingemanse, Jasper
    Kraehenbuehl, Stephan
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 38 (04) : 384 - 388
  • [30] Separation and Characterization of New Forced Degradation Products of Macitentan: A Dual Endothelin Receptor Antagonist
    Mohit Thummar
    Debasish Swain
    S. Gananadhamu
    Chromatographia, 2018, 81 : 525 - 531
12345