The Virologic and Immunologic Effects of Cyclosporine as an Adjunct to Antiretroviral Therapy in Patients Treated during Acute and Early HIV-1 Infection

被引：26

作者：

Markowitz, Martin ^{[1
]}

Vaida, Florin ^{[4
,5
]}

Hare, C. Bradley ^{[4
]}

Boden, Daniel ^{[1
]}

Mohri, Hiroshi ^{[1
]}

Hecht, Frederick M. ^{[4
]}

Kalayjian, Robert C. ^{[7
]}

Conrad, Ann ^{[7
]}

Mildvan, Donna ^{[2
]}

Aberg, Judith ^{[3
]}

Hogan, Christine ^{[1
]}

Kilby, J. Michael ^{[8
]}

Balfour, Henry H., Jr. ^{[9
]}

Schafer, Kim ^{[4
,5
]}

Richman, Douglas ^{[4
,5
,6
]}

Little, Susan ^{[4
,5
]}

机构：

[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Beth Israel Deaconess Med Ctr, Dept Med, Div Infect Dis, New York, NY 10003 USA

[3] NYU, Sch Med, Dept Med, Div Infect Dis, New York, NY USA

[4] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA

[5] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA

[6] Vet Adm San Diego Healthcare Syst, San Diego, CA USA

[7] Metrohlth Med Ctr, Dept Med, Cleveland, OH USA

[8] Univ Alabama, Dept Med, Birmingham, AL 35294 USA

[9] Univ Minnesota, Minneapolis, MN USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷 / 09期

基金：

美国国家卫生研究院;

关键词：

CD4(+) T-LYMPHOCYTES; GASTROINTESTINAL-TRACT; DEPLETION;

D O I：

10.1086/651664

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4(+) T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.

引用

页码：1298 / 1302

页数：5

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