Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

被引:14
作者
Banerjee, Jennifer J. [1 ]
Aerne, Birgit L. [1 ]
Holder, Maxine V. [1 ]
Hauri, Simon [2 ,3 ,4 ]
Gstaiger, Matthias [2 ,3 ]
Tapon, Nicolas [1 ]
机构
[1] Francis Crick Inst, Apoptosis & Proliferat Control Lab, London, England
[2] Swiss Fed Inst Technol, Inst Mol Syst Biol, Dept Biol, Zurich, Switzerland
[3] Competence Ctr Personalized Med UZH ETH, Zurich, Switzerland
[4] Lund Univ, Dept Clin Sci, Lund, Sweden
来源
ELIFE | 2017年 / 6卷
基金
英国惠康基金;
关键词
ORGAN PRECURSOR CELL; DROSOPHILA-MELANOGASTER; SPINDLE ORIENTATION; GENE-EXPRESSION; NERVOUS-SYSTEM; FATE DECISION; DISCS-LARGE; PROTEIN; LOCALIZATION; BAZOOKA;
D O I
10.7554/eLife.25014
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery.
引用
收藏
页数:21
相关论文
共 72 条
[1]   Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4 [J].
Aerne, Birgit L. ;
Gailite, Ieva ;
Sims, David ;
Tapon, Nicolas .
PLOS ONE, 2015, 10 (06)
[2]   The PCP pathway regulates Baz planar distribution in epithelial cells [J].
Aigouy, Benoit ;
Le Bivic, Andre .
SCIENTIFIC REPORTS, 2016, 6
[3]   The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila [J].
Bellaïche, Y ;
Beaudoin-Massiani, O ;
Stüttem, I ;
Schweisguth, F .
DEVELOPMENT, 2004, 131 (02) :469-478
[4]   The partner of inscuteable/discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila [J].
Bellaïche, Y ;
Radovic, A ;
Woods, DF ;
Hough, CD ;
Parmentier, ML ;
O'Kane, CJ ;
Bryant, PJ ;
Schweisguth, F .
CELL, 2001, 106 (03) :355-366
[5]   Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division [J].
Bellaïche, Y ;
Gho, M ;
Kaltschmidt, JA ;
Brand, AH ;
Schweisguth, F .
NATURE CELL BIOLOGY, 2001, 3 (01) :50-57
[6]   Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells [J].
Benton, R ;
St Johnston, D .
CELL, 2003, 115 (06) :691-704
[7]   Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells [J].
Besson, Charlotte ;
Bernard, Fred ;
Corson, Francis ;
Rouault, Herve ;
Reynaud, Elodie ;
Keder, Alyona ;
Mazouni, Khalil ;
Schweisguth, Francois .
CURRENT BIOLOGY, 2015, 25 (08) :1104-1110
[8]   Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling [J].
Boutros, M ;
Paricio, N ;
Strutt, DI ;
Mlodzik, M .
CELL, 1998, 94 (01) :109-118
[9]   The Drosophila NuMA homolog mud regulates spindle orientation in asymmetric cell division [J].
Bowman, Sarah K. ;
Neumueller, Ralph A. ;
Novatchkova, Maria ;
Du, Quansheng ;
Knoblich, Juergen A. .
DEVELOPMENTAL CELL, 2006, 10 (06) :731-742
[10]   From cells to organs: building polarized tissue [J].
Bryant, David M. ;
Mostov, Keith E. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (11) :887-901