Circadian clocks organize behavior and physiology to adapt to daily environmental cycles. Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely conserved molecular gears of these 24-h timers. Yet much less is known about how these cell-autonomous clocks confer temporal information to modulate cellular functions. Here we discuss our current knowledge of circadian clock function in Drosophila, providing an overview of the molecular underpinnings of circadian clocks. We then describe the neural network important for circadian rhythms of locomotor activity, including how these molecular clocks might influence neuronal function. Finally, we address a range of behaviors and physiological systems regulated by circadian clocks, including discussion of specific peripheral oscillators and key molecular effectors where they have been described. These studies reveal a remarkable complexity to circadian pathways in this "simple" model organism.
机构:
Northwestern Univ, Dept Neurobiol & Physiol, 2205 Tech Dr 2-160, Evanston, IL 60208 USANorthwestern Univ, Dept Neurobiol & Physiol, 2205 Tech Dr 2-160, Evanston, IL 60208 USA
Allada, Ravi
Siegel, Jerome M.
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机构:
Univ Calif Los Angeles, Sch Med, Dept Psychiat, VA GLAHS Sepulveda, North Hills, CA 91343 USA
Univ Calif Los Angeles, Sch Med, Brain Res Inst, North Hills, CA 91343 USANorthwestern Univ, Dept Neurobiol & Physiol, 2205 Tech Dr 2-160, Evanston, IL 60208 USA
机构:
Northwestern Univ, Dept Neurobiol & Physiol, 2205 Tech Dr 2-160, Evanston, IL 60208 USANorthwestern Univ, Dept Neurobiol & Physiol, 2205 Tech Dr 2-160, Evanston, IL 60208 USA
Allada, Ravi
Siegel, Jerome M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Sch Med, Dept Psychiat, VA GLAHS Sepulveda, North Hills, CA 91343 USA
Univ Calif Los Angeles, Sch Med, Brain Res Inst, North Hills, CA 91343 USANorthwestern Univ, Dept Neurobiol & Physiol, 2205 Tech Dr 2-160, Evanston, IL 60208 USA