Circadian Organization of Behavior and Physiology in Drosophila

被引:328
作者
Allada, Ravi [1 ]
Chung, Brian Y. [1 ]
机构
[1] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA
关键词
peripheral clocks; pacemaker neurons; locomotor activity; feeding; mating; CHANNEL BINDING-PROTEIN; PERIOD CLOCK GENE; TRANSCRIPTIONAL REPRESSOR; OLFACTORY RESPONSES; LOCOMOTOR-ACTIVITY; MUTANT DROSOPHILA; NATURAL-SELECTION; SLEEP-DEPRIVATION; TAKEOUT GENE; PDF NEURONS;
D O I
10.1146/annurev-physiol-021909-135815
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Circadian clocks organize behavior and physiology to adapt to daily environmental cycles. Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely conserved molecular gears of these 24-h timers. Yet much less is known about how these cell-autonomous clocks confer temporal information to modulate cellular functions. Here we discuss our current knowledge of circadian clock function in Drosophila, providing an overview of the molecular underpinnings of circadian clocks. We then describe the neural network important for circadian rhythms of locomotor activity, including how these molecular clocks might influence neuronal function. Finally, we address a range of behaviors and physiological systems regulated by circadian clocks, including discussion of specific peripheral oscillators and key molecular effectors where they have been described. These studies reveal a remarkable complexity to circadian pathways in this "simple" model organism.
引用
收藏
页码:605 / 624
页数:20
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