Vitamin B-12 treatment for delayed sleep phase syndrome: A multi-center double-blind study

被引：24

作者：

Okawa, M

Takahashi, K

Egashira, K

Furuta, H

Higashitani, Y

Higuchi, T

Ichikawa, H

Ichimaru, Y

Inoue, Y

Ishizuka, Y

Ito, N

Kamei, K

Kaneko, M

Kim, Y

Kohsaka, M

Komori, T

Kotorii, T

Matsumoto, M

Mishima, K

Mizuki, Y

Morimoto, K

Nagayama, H

Ohta, T

Okamoto, N

Sakamoto, K

Shirakawa, S

Sugita, Y

Tamiya, S

Yamada, N

Yamadera, H

Yamazaki, J

Takahashi, S

机构：

[1] NCNP, NATL INST MENTAL HLTH, CHIBA, 807, JAPAN

[2] UNIV OCCUPAT & ENVIRONM HLTH, DEPT PSYCHIAT, KITAKYUSHU, FUKUOKA 920, JAPAN

[3] KANAZAWA UNIV, SCH MED, DEPT NEUROPSYCHIAT, KANAZAWA 99023, ISHIKAWA, JAPAN

[4] YAMAGATA UNIV, SCH MED, DEPT NEUROPSYCHIAT, YAMAGATA, 227, JAPAN

[5] SHOWA UNIV, FUJIGAOKA HOSP, DEPT NEUROPSYCHIAT, YOKOHAMA, KANAGAWA, JAPAN

[6] TOKYO METROPOLITAN UMEGAOKA HOSP, TOKYO, JAPAN

[7] DOKKYO UNIV, SCH MED, DEPT NEUROL, MIBU 680, TOCHIGI, JAPAN

[8] TOTTORI UNIV, FAC MED, DEPT NEUROPSYCHIAT, TOTTORI 40938, JAPAN

[9] YAMANASHI MED COLL, DEPT PSYCHIAT, YAMANASHI 76107, JAPAN

[10] KAGAWA MED SCH, DEPT NEUROPSYCHIAT, KAGAWA 890, JAPAN

[11] KAGOSHIMA UNIV, SCH MED, DEPT NEUROPSYCHIAT, KAGOSHIMA, JAPAN

[12] FUKUSHIMA MED COLL, DEPT NEUROPSYCHIAT, FUKUSHIMA, JAPAN

[13] TOYAMA MED & PHARMACEUT UNIV, SCH MED, DEPT NEUROPSYCHIAT, TOYAMA, 060, JAPAN

[14] HOKKAIDO UNIV, SCH MED, DEPT PSYCHIAT & NEUROL, SAPPORO, HOKKAIDO 514, JAPAN

[15] MIE UNIV, SCH MED, DEPT PSYCHIAT, TSU, MIE 830, JAPAN

[16] KURUME UNIV, SCH MED, DEPT NEUROPSYCHIAT, KURUME, FUKUOKA 078, JAPAN

[17] ASAHIKAWA MED COLL, DEPT PSYCHIAT & NEUROL, ASAHIKAWA 010, HOKKAIDO, JAPAN

[18] AKITA UNIV, SCH MED, DEPT NEUROPSYCHIAT, AKITA, 755, JAPAN

[19] YAMAGUCHI UNIV, SCH MED, DEPT NEUROPSYCHIAT, UBE 700, YAMAGUCHI, JAPAN

[20] OKAYAMA UNIV, SCH MED, DEPT NEUROPSYCHIAT, OKAYAMA, JAPAN

[21] OITA MED UNIV, DEPT NEUROPSYCHIAT, OITA, 466, JAPAN

[22] NAGOYA UNIV, SCH MED, DEPT PSYCHIAT, NAGOYA, AICHI 43131, JAPAN

[23] HAMAMATSU UNIV SCH MED, DEPT PSYCHIAT, HAMAMATSU 162, SHIZUOKA, JAPAN

[24] TOKYO WOMENS MED COLL, TOKYO 553, JAPAN

[25] OSAKA UNIV, SCH MED, DEPT NEUROPSYCHIAT, OSAKA, JAPAN

[26] HIROSHIMA UNIV, SCH MED, DEPT NEUROPSYCHIAT, HIROSHIMA, 52021, JAPAN

[27] SHIGA UNIV MED SCI, DEPT PSYCHIAT, OTSU 113, SHIGA, JAPAN

[28] NIPPON MED COLL, DEPT NEUROPSYCHIAT, TOKYO, 35004, JAPAN

[29] SAITAMA MED SCH, DEPT NEUROPSYCHIAT, MOROYAMA, SAITAMA, JAPAN

[30] NCNP, NATL CTR HOSP MENTAL NERVOUS & MUSCULAR DISORDERS, TOKYO, JAPAN

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 1997年 / 51卷 / 05期

关键词：

delayed sleep phase syndrome; sleep-log; vitamin B-12 (methylcobalamin);

D O I：

10.1111/j.1440-1819.1997.tb03198.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The active form of vitamin B-12 (methylcobalamin) has been reported to be effective on sleep-wake rhythm disorders. Previous studies, however, were performed under open trial, and the effect of vitamin B-12 has not been properly evaluated. The aim of this double-blind study was to investigate the efficacy of methylcobalamin on delayed sleep phase syndrome (DSPS). Methylcobalamin (3 mg/day) or placebo was administered for 4 weeks. The subjects were 50 patients with DSPS aged 13-55 years (26.5 +/- 1.3), 27 of whom received the active drug while 23 received the placebo. No significant differences were observed between the 2 groups in subjective evaluations of mood or drowsiness during the daytime or in night sleep by sleep-log evaluation. These results indicate that 3 mg methylcobalamin administered over 4 weeks is not an effective treatment for DSPS.

引用

页码：275 / 279

页数：5

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