Synthesis of 2,2′-Bipyridines via Suzuki-Miyaura Cross-Coupling

被引:28
|
作者
Guetz, Christoph [1 ]
Luetzen, Arne [1 ]
机构
[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany
来源
SYNTHESIS-STUTTGART | 2010年 / 01期
关键词
cross-coupling reactions; bipyridines; palladium; 2-pyridylboronic acid esters; Suzuki-Miyaura reaction; BIPYRIDINE; PYRIDINES; ESTERS; ACIDS;
D O I
10.1055/s-0029-1217082
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
For a long time, the Suzuki-Miyaura cross-coupling reaction could not be used for the synthesis of 2,2'-bipyridines due to the lack of sufficiently stable 2-pyridylboron compounds. Stabilized 2-pyridylboronic acid esters recently developed by Hodgson, however, were found to be ideally suited for this purpose. Two general protocols could be developed and demonstrated to be valuable alternatives, which can be used very efficiently for the synthesis of functionalized 2,2'-bipyridines.
引用
收藏
页码:85 / 90
页数:6
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