Synthesis of 2,2′-Bipyridines via Suzuki-Miyaura Cross-Coupling

被引：28

作者：

Guetz, Christoph ^{[1
]}

Luetzen, Arne ^{[1
]}

机构：

[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

来源：

SYNTHESIS-STUTTGART | 2010年 / 01期

关键词：

cross-coupling reactions; bipyridines; palladium; 2-pyridylboronic acid esters; Suzuki-Miyaura reaction; BIPYRIDINE; PYRIDINES; ESTERS; ACIDS;

D O I：

10.1055/s-0029-1217082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

For a long time, the Suzuki-Miyaura cross-coupling reaction could not be used for the synthesis of 2,2'-bipyridines due to the lack of sufficiently stable 2-pyridylboron compounds. Stabilized 2-pyridylboronic acid esters recently developed by Hodgson, however, were found to be ideally suited for this purpose. Two general protocols could be developed and demonstrated to be valuable alternatives, which can be used very efficiently for the synthesis of functionalized 2,2'-bipyridines.

引用

页码：85 / 90

页数：6

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