Synthesis of new pyrrolo[2,1-a] phthalazine derivatives via multicomponent reaction of phthalazine with 1,1-dicyanoalkenes and alkyl isocyanides

被引：5
|
作者：
Mironov, Maxim A. [1 ]
Shulepov, Iliya D. [1 ]
Kozhikhova, Ksenia V. [1 ]
Ivantsova, Maria N. [1 ]
Tokareva, Maria I. [1 ]
机构：
[1] Ural Fed Univ, Dept Technol Organ Synth, 19 Mir St, Ekaterinburg 620002, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2017年 / 53卷 / 04期
关键词：
isocyanides; phthalazine; decarboxylation; multicomponent reaction; one-pot synthesis; FLUORESCENT PYRROLOPYRIDAZINE DERIVATIVES; CYCLOADDITIONS; WATER;
D O I：
10.1007/s10593-017-2071-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Multicomponent reactions between phthalazine, alkyl isocyanides, and 1,1-dicyanoalkenes in acetonitrile-water mixture produced high yields of substituted pyrrolo[2,1-a]phthalazines, which were converted upon treatment with 10% hydrochloric acid to pyrrolo[2,1-a]-phthalazines unsubstituted at position 1. As a result, a range of new pyrrolo[2,1-a]phthalazine derivatives have been synthesized by this one-pot approach.
引用
收藏
页码：430 / 433
页数：4
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