HLA common and well-documented alleles in China

被引:111
作者
He, Y. [1 ,2 ]
Li, J. [3 ]
Mao, W. [4 ]
Zhang, D. [5 ]
Liu, M. [6 ]
Shan, X. [7 ]
Zhang, B. [8 ]
Zhu, C. [9 ]
Shen, J. [10 ]
Deng, Z. [11 ]
Wang, Z. [12 ]
Yu, W. [13 ]
Chen, Q. [14 ,15 ]
Guo, W. [16 ]
Su, P. [17 ]
Lv, R. [18 ]
Li, G. [19 ,20 ]
Li, G. [19 ,20 ]
Pei, B. [21 ]
Jiao, L. [22 ]
Shen, G. [23 ]
Liu, Y. [24 ]
Feng, Z. [25 ]
Su, Y. [26 ]
Xie, Y. [27 ]
Di, W. [28 ]
Liu, X. [29 ]
Yang, X. [30 ]
Wang, J. [14 ,15 ]
Qi, J. [6 ]
Liu, Q. [31 ]
Han, Y. [31 ]
He, J. [32 ]
Cai, J. [33 ,34 ]
Zhang, Z. [7 ]
Zhu, F. [1 ,2 ]
Du, D. [31 ]
机构
[1] Blood Ctr Zhejiang Prov, HLA Lab, Hangzhou, Zhejiang, Peoples R China
[2] Key Lab Blood Safety Res Zhejiang Prov, HLA Lab, Hangzhou, Zhejiang, Peoples R China
[3] Liaoning Blood Ctr, HLA Lab, Shenyang, Liaoning, Peoples R China
[4] Chongqing Blood Ctr, HLA Lab, Chongqing, Peoples R China
[5] Taiyuan Red Cross Blood Ctr, HLA Lab, Taiyuan, Peoples R China
[6] Shanxi Blood Ctr, HLA Lab, Xian, Shaanxi, Peoples R China
[7] Beijing Red Cross Blood Ctr, HLA Lab, Beijing, Peoples R China
[8] Henan Blood Ctr, HLA Lab, Zhengzhou, Henan, Peoples R China
[9] Shandong Blood Ctr, HLA Lab, Jinan, Shandong, Peoples R China
[10] Nanjing Med Univ, Affiliated Hosp 1, HLA Lab, Nanjing, Jiangsu, Peoples R China
[11] Shenzhen Blood Ctr, Key Lab Histocompatibil & Immunogenet, Shenzhen, Peoples R China
[12] Hebei Blood Ctr, HLA Lab, Shijiazhuang, Hebei, Peoples R China
[13] Dalian Red Cross Blood Ctr, HLA Lab, Dalian, Peoples R China
[14] Chinese Acad Med Sci, Inst Blood Transfus, HLA Lab, Chengdu, Sichuan, Peoples R China
[15] Peking Union Med Coll, Chengdu, Sichuan, Peoples R China
[16] Xinjiang Blood Ctr, HLA Lab, Urumqi, Peoples R China
[17] Kunming Blood Ctr, HLA Lab, Kunming, Yunnan, Peoples R China
[18] Hefei Red Cross Blood Ctr, HLA Lab, Hefei, Anhui, Peoples R China
[19] Gansu Red Cross Blood Ctr, HLA Lab, Lanzhou, Gansu, Peoples R China
[20] Jiangxi Blood Ctr, HLA Lab, Nanchang, Jiangxi, Peoples R China
[21] Xiamen Blood Ctr, HLA Lab, Xiamen, Peoples R China
[22] Changchun Blood Ctr, HLA Lab, Changchun, Jilin, Peoples R China
[23] Wuhan Blood Ctr, HLA Lab, Wuhan, Hubei, Peoples R China
[24] Harbin Red Cross Blood Ctr, HLA Lab, Harbin, Heilongjiang, Peoples R China
[25] Qingdao Blood Ctr, HLA Lab, Qingdao, Peoples R China
[26] Yueyang Red Cross Blood Ctr, HLA Lab, Yueyang, Peoples R China
[27] Changsha Blood Ctr, HLA Lab, Changsha, Hunan, Peoples R China
[28] Soochow Red Cross Blood Ctr, HLA Lab, Suzhou, Peoples R China
[29] CapitalBio Corp, HLA Lab, Beijing, Peoples R China
[30] Beijing Genom Inst, HLA Lab, Shenzhen, Peoples R China
[31] China Marrow Donor Program, Dept Tech Serv, Beijing 100073, Peoples R China
[32] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Dept HLA Lab, Suzhou, Peoples R China
[33] Minist Hlth, Beijing Hosp, Beijing Inst Geriatr, Key Lab Geriatr, Beijing, Peoples R China
[34] China Bone Marrow Program, Qual Control Lab, Beijing, Peoples R China
关键词
ASHI; Chinese population; common and well-documented allele; EFI; HLA; LEUKOCYTE ANTIGEN-A; HIGH-RESOLUTION; UNRELATED DONOR; MOLECULAR-MECHANISM; POPULATION; CATALOG; TRANSPLANTATION; IMMUNOGENETICS; GENERATION; RISK;
D O I
10.1111/tan.13358
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The American Society for Histocompatibility and Immunogenetics HLA common and well-documented (CWD) catalog, CWD 2.0.0 catalog and European Federation for Immunogenetics (EFI) CWD catalog have been published, which are useful for improving the accuracy of HLA genotyping in laboratories. Here, we studied the Chinese HLA CWD catalog. A total of 812211 unrelated volunteer donors from the China Marrow Donor Program (CMDP) were analyzed. Six hundred seventy-six alleles at the HLA-A, -B, -C, -DRB1, and -DQB1 loci were defined as CWD alleles in the Chinese population, including 159 common and 517 well-documented alleles. The distribution of HLA alleles in the Chinese CWD catalog is different from that in the EFI CWD catalog. Thirty-two percent (215/676) of CWD alleles in the Chinese CWD catalog are shared with those in the EFI CWD catalog. Fifty-six percent (380/676) of alleles in the Chinese CWD catalog are not found in the EFI CWD catalog, while 655 alleles in the EFI CWD catalog are neither common nor well-documented alleles in the Chinese CWD catalog. The Chinese CWD catalog described in this study may help to improve high-resolution histocompatibility testing for CMDP-accredited laboratories in China. However, to accommodate an increasing number of HLA alleles, this Chinese CWD catalog should be regularly updated.
引用
收藏
页码:199 / 205
页数:7
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