VAV1 Gene Polymorphism is Associated With Kidney Allograft Rejection

被引：2

作者：

Wisniewska, Magda ^{[1
]}

Banach, Boleslaw ^{[2
]}

Malinowski, Damian ^{[3
]}

Domanski, Leszek ^{[1
]}

Sroczynski, Tomasz ^{[2
]}

Dziedziejko, Violetta ^{[4
]}

Safranow, Krzysztof ^{[4
]}

Pawlik, Andrzej ^{[2
]}

机构：

[1] Pomeranian Med Univ, Dept Nephrol Transplantol & Internal Med, Szczecin, Poland

[2] Pomeranian Med Univ, Dept Physiol, Szczecin, Poland

[3] Pomeranian Med Univ, Dept Pharmacol, Szczecin, Poland

[4] Pomeranian Med Univ, Dept Biochem & Med Chem, Szczecin, Poland

来源：

TRANSPLANTATION PROCEEDINGS | 2021年 / 53卷 / 05期

关键词：

KAPPA-B ACTIVATION; T-CELLS; CD28; SURVIVAL; INDUCTION; RAC2;

D O I：

10.1016/j.transproceed.2021.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. VAV1 is an intracellular signal transduction protein that plays a significant role in signal transduction in T cells. Several studies suggest that VAV1 signaling plays significant roles in allograft rejection. The aim of this study was to examine the association between VAV1 gene polymorphisms and renal allograft function. Methods. The study included 270 patients after allograft renal transplantation. We examined the associations between VAV1 gene polymorphisms and complications after transplantation, such as delayed graft function, acute rejection, and chronic allograft dysfunction. Results. There were no statistically significant associations between VAV1 genotypes and delayed graft function and chronic allograft dysfunction. Among patients with acute allograft rejection, we observed decreased frequencies of VAV1 rs2546133 TT and CT genotypes (P = .03) and T allele (P = .02), as well as VAV1 rs2617822 GG and AG genotypes (P = .05) and G allele (P = 0.04). In the multivariate regression analysis, the higher number of VAV1 rs2546133 T alleles showed a protective effect against the acute rejection in kidney allograft recipients. Conclusions. The results of our study suggest that polymorphisms in the VAV1 gene are associated with kidney allograft rejection.

引用

页码：1528 / 1531

页数：4

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