Dissecting ICRAC, a store-operated calcium current

被引:95
作者
Hogan, Patrick G.
Rao, Anjana
机构
[1] Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
关键词
D O I
10.1016/j.tibs.2007.03.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The use of Ca2+ for intracellular signalling necessitates tight local and global control of cytoplasmic Ca2+ concentration, and mechanisms for maintaining the net Ca2+ balance. It has long been recognized that intracellular Ca2+ stores exert control over Ca2+ influx at the plasma membrane through a process of store-operated Ca2+ entry (SOCE). The Ca2+ current I-CRAC is the best characterized instance of SOCE, but the elements of the pathway leading to I-CRAC have eluded biochemical definition for more than a decade. However, the recent identification of key proteins underlying I-CRAC-STIM1 and Orai1 - has led to several insights into this ER-to-plasma membrane signalling system and to the recognition that it is an ancient and conserved mechanism in multicellular organisms.
引用
收藏
页码:235 / 245
页数:11
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