Multiregion Comprehensive Genomic Profiling of a Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Trilineage Differentiation

被引：12

作者：

Farooq, Faheem ^{[1
]}

Zarrabi, Kevin ^{[1
]}

Sweeney, Keith ^{[2
]}

Kim, Joseph ^{[3
]}

Bandovic, Jela ^{[2
]}

Patel, Chiraag ^{[2
,4
]}

Choi, Minsig ^{[1
,5
]}

机构：

[1] Stony Brook Univ Hosp, Dept Med, Stony Brook, NY 11794 USA

[2] Stony Brook Univ Hosp, Dept Pathol, Stony Brook, NY 11794 USA

[3] Stony Brook Univ Hosp, Dept Surg, Stony Brook, NY 11794 USA

[4] Stony Brook Univ Hosp, Dept Pathol, Lab Mol Genet, Stony Brook, NY 11794 USA

[5] Stony Brook Univ Hosp, Dept Med, Div Hematol Oncol, HSC 15-053C,101 Nicholls Rd, Stony Brook, NY 11794 USA

来源：

JOURNAL OF GASTRIC CANCER | 2018年 / 18卷 / 02期

关键词：

Neuroendocrine neoplasm; Gastric cancer; Precision medicine; SQUAMOUS-CELL CARCINOMA; ADENONEUROENDOCRINE CARCINOMA; CANCER; TUMORS; TELOMERASE; ADENO;

D O I：

10.5230/jgc.2018.18.e16

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) are a group of rare tumors previously known as mixed adenoneuroendocrine carcinomas (MANECs). The neuroendocrine component is high-grade and may consist of small-cell carcinoma or large-cell neuroendocrine carcinoma. The nonneuroendocrine component may consist of adenocarcinoma or squamous cell carcinoma. We report a unique case of a MiNEN with trilineage differentiation: large-cell neuroendocrine carcinoma, squamous cell carcinoma, and adenocarcinoma. The reported patient presented with symptoms of an upper gastrointestinal bleed and was ultimately diagnosed with a MiNEN with trilineage differentiation. This is the first report of this exceedingly rare tumor type to include next-generation sequencing of the 3 separate tumor entities. In addition, we review the current literature and discuss the role of next-generation sequencing in classifying and treating MiNEN tumors.

引用

页码：200 / 207

页数：8

共 26 条

[1] Gastric Mixed Adenoneuroendocrine Carcinoma with Squamous Differentiation: A Case Report [J].

Bae, Han-Ik ;

Lee, Chaeyoon ;

Jo, Young-Min ;

Kwon, Ohkyung ;

Yu, Wansik ;

Kim, Mee-Seon ;

Seo, An Na .

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, 2016, 50 (04) :318-321

[2] Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial [J].

Bang, Yung-Jue ;

Kim, Young-Woo ;

Yang, Han-Kwang ;

Chung, Hyun Cheol ;

Park, Young-Kyu ;

Lee, Kyung Hee ;

Lee, Keun-Wook ;

Kim, Yong Ho ;

Noh, Sang-Ik ;

Cho, Jae Yong ;

Mok, Young Jae ;

Kim, Yeul Hong ;

Ji, Jiafu ;

Yeh, Ta-Sen ;

Button, Peter ;

Sirzen, Florin ;

Noh, Sung Hoon .

LANCET, 2012, 379 (9813) :315-321

[3] Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis [J].

Blakeley, Jaishri O. ;

Plotkin, Scott R. .

NEURO-ONCOLOGY, 2016, 18 (05) :624-638

[4] Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications [J].

Boscolo-Rizzo, Paolo ;

Da Mosto, Maria Cristina ;

Rampazzo, Enrica ;

Giunco, Silvia ;

Del Mistro, Annarosa ;

Menegaldo, Anna ;

Baboci, Lorena ;

Mantovani, Monica ;

Tirelli, Giancarlo ;

De Rossi, Anita .

CANCER AND METASTASIS REVIEWS, 2016, 35 (03) :457-474

[5] Appendiceal Mixed Adeno-Neuroendocrine Carcinoma: A Population-Based Study of the Surveillance, Epidemiology, and End Results Registry [J].

Brathwaite, Shayna ;

Yearsley, Martha M. ;

Bekaii-Saab, Tanios ;

Wei, Lai ;

Schmidt, Carl R. ;

Dillhoff, Mary E. ;

Frankel, Wendy L. ;

Hays, John L. ;

Wu, Christina ;

Abdel-Misih, Sherif .

FRONTIERS IN ONCOLOGY, 2016, 6

[6] Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells [J].

Cao, Ying ;

Bryan, Tracy M. ;

Reddel, Roger R. .

CANCER SCIENCE, 2008, 99 (06) :1092-1099

[7] Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers [J].

Finn, Richard S. ;

Aleshin, Alexey ;

Slamon, Dennis J. .

BREAST CANCER RESEARCH, 2016, 18

[8] Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing [J].

Frampton, Garrett M. ;

Fichtenholtz, Alex ;

Otto, Geoff A. ;

Wang, Kai ;

Downing, Sean R. ;

He, Jie ;

Schnall-Levin, Michael ;

White, Jared ;

Sanford, Eric M. ;

An, Peter ;

Sun, James ;

Juhn, Frank ;

Brennan, Kristina ;

Iwanik, Kiel ;

Maillet, Ashley ;

Buell, Jamie ;

White, Emily ;

Zhao, Mandy ;

Balasubramanian, Sohail ;

Terzic, Selmira ;

Richards, Tina ;

Banning, Vera ;

Garcia, Lazaro ;

Mahoney, Kristen ;

Zwirko, Zac ;

Donahue, Amy ;

Beltran, Himisha ;

Mosquera, Juan Miguel ;

Rubin, Mark A. ;

Dogan, Snjezana ;

Hedvat, Cyrus V. ;

Berger, Michael F. ;

Pusztai, Lajos ;

Lechner, Matthias ;

Boshoff, Chris ;

Jarosz, Mirna ;

Vietz, Christine ;

Parker, Alex ;

Miller, Vincent A. ;

Ross, Jeffrey S. ;

Curran, John ;

Cronin, Maureen T. ;

Stephens, Philip J. ;

Lipson, Doron ;

Yelensky, Roman .

NATURE BIOTECHNOLOGY, 2013, 31 (11) :1023-+

[9] Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut [J].

Furlan, D ;

Cerutti, R ;

Genasetti, A ;

Pelosi, G ;

Uccella, S ;

La Rosa, S ;

Capella, C .

LABORATORY INVESTIGATION, 2003, 83 (07) :963-971

[10] Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors [J].

George, Julie ;

Walter, Vonn ;

Peifer, Martin ;

Alexandrov, Ludmil B. ;

Seidel, Danila ;

Leenders, Frauke ;

Maas, Lukas ;

Mueller, Christian ;

Dahmen, Ilona ;

Delhomme, Tiffany M. ;

Ardin, Maude ;

Leblay, Noemie ;

Byrnes, Graham ;

Sun, Ruping ;

De Reynies, Aurelien ;

McLeer-Florin, Anne ;

Bosco, Graziella ;

Malchers, Florian ;

Menon, Roopika ;

Altmuller, Janine ;

Becker, Christian ;

Nurnberg, Peter ;

Achter, Viktor ;

Lang, Ulrich ;

Schneider, Peter M. ;

Bogus, Magdalena ;

Soloway, Matthew G. ;

Wilkerson, Matthew D. ;

Cun, Yupeng ;

McKay, James D. ;

Moro-Sibilot, Denis ;

Brambilla, Christian G. ;

Lantuejoul, Sylvie ;

Lemaitre, Nicolas ;

Soltermann, Alex ;

Weder, Walter ;

Tischler, Verena ;

Brustugun, Odd Terje ;

Lund-Iversen, Marius ;

Helland, Aslaug ;

Solberg, Steinar ;

Ansen, Sascha ;

Wright, Gavin ;

Solomon, Benjamin ;

Roz, Luca ;

Pastorino, Ugo ;

Petersen, Iver ;

Clement, Joachim H. ;

Saenger, Jorg ;

Wolf, Jurgen .

NATURE COMMUNICATIONS, 2018, 9

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