Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens

被引：45

作者：

Keyes, RF ^{[1
]}

Carter, JJ ^{[1
]}

Englund, EE ^{[1
]}

Daly, MM ^{[1
]}

Stone, GG ^{[1
]}

Nilius, AM ^{[1
]}

Ma, ZK ^{[1
]}

机构：

[1] Abbott Labs, Infect Dis Res, Abbott Pk, IL 60064 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 10期

关键词：

D O I：

10.1021/jm025580k

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel 6-O-substituted homopropargyl ketolides was synthesized and evaluated against various erythromycin-resistant pathogens. Promising in vitro antibacterial activity was demonstrated for compounds bearing this structural motif.

引用

页码：1795 / 1798

页数：4

共 17 条

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