Quinazolinones from o-Aminobenzonitriles by One-Pot Sequential Selective Hydration/Condensation/Acceptorless Dehydrogenation Catalyzed by an Iridium Complex

被引：45

作者：

Zhao, Wei ^{[1
]}

Liu, Pengcheng ^{[1
]}

Li, Feng ^{[1
,2
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, 200 Xiaolingwei St, Nanjing 210094, Jiangsu, Peoples R China

[2] Dalian Univ Technol, State Key Lab Fine Chem, 2 Lingong Rd, Dalian 116024, Peoples R China

来源：

CHEMCATCHEM | 2016年 / 8卷 / 08期

基金：

中国国家自然科学基金;

关键词：

dehydrogenation; heterocycles; homogeneous catalysis; iridium; synthesis design; FUNCTIONAL BIPYRIDONATE LIGAND; N-ALKYLATED AMIDES; ACCEPTORLESS DEHYDROGENATION; PRIMARY ALCOHOLS; NITROGEN-HETEROCYCLES; HYDROGENATION; INHIBITORS; SYSTEM; OXIDATION; NITRILES;

D O I：

10.1002/cctc.201501385

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new strategy for the direct synthesis of quinazolinones from o-aminobenzonitriles was proposed and accomplished. In the presence of [Cp*IrCl2](2) (Cp*=pentamethylcyclopentadienyl), a variety of desirable products was obtained easily through the one-pot sequential selective hydration/condensation/acceptorless dehydrogenation. This protocol is highly attractive because it uses readily available starting materials, has a high atom efficiency, good to excellent yields, and minimal consumption of chemicals and energy. Notably, this research exhibited new potential for the development of transition-metal-catalyzed one-pot sequential reactions that involve acceptorless dehydrogenation.

引用

页码：1523 / 1530

页数：8

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