Improved Detection of Tuberculosis and Multidrug-Resistant Tuberculosis among Tibetan Refugees, India

被引：21

作者：

Dierberg, Kerry L. ^{[1
]}

Dorjee, Kunchok ^{[2
,3
]}

Salvo, Fulvio ^{[4
]}

Cronin, Wendy A. ^{[5
]}

Boddy, J'Belle ^{[1
]}

Cirillo, Daniela ^{[4
]}

Sadutshang, Tsetan ^{[2
,3
]}

Chaisson, Richard E. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[2] Tibetan Delek Hosp, Dharmshala, India

[3] Cent Tibetan Adm, Dept Hlth, Dharmshala, India

[4] Ist Sci San Raffaele, I-20132 Milan, Italy

[5] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.3201/eid2203.140732

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The incidence of tuberculosis (TB) among Tibetan refugees in India is 431 cases/100,000 persons, compared with 181 cases/100,000 persons overall in India in 2010. More than half of TB cases in these refugees occur among students, monks, and nuns in congregate settings. We sought to increase TB case detection rates for this population through active case finding and rapid molecular diagnostics. We screened 27,714 persons for symptoms of TB and tested 3,830 symptomatic persons by using an algorithm incorporating chest radiography, sputum smear microscopy, culture, and a rapid diagnostic test; 96 (2.5%) cases of TB were detected (prevalence 346 cases/100,000 persons). Of these cases, 5% were multidrug-resistant TB. Use of the rapid diagnostic test and active case finding enabled rapid detection of undiagnosed TB cases in congregate living settings, which would not have otherwise been identified. The burden of TB in the Tibetan exile population in India is extremely high and requires urgent attention.

引用

页码：463 / 468

页数：6

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