MicroRNAs in Cerebrovascular Diseases - from Pathophysiology to Potential Biomarkers

被引：0

作者：

Volny, O. ^{[1
,2
]}

Kasickova, L. ^{[3
]}

Coufalova, D. ^{[2
,3
]}

Cimflova, P. ^{[2
,4
]}

Novak, J. ^{[5
,6
]}

机构：

[1] LF MU & FN Sv Anny Brne, Neurol Klin 1, Brno, Czech Republic

[2] FN Sv Anny Brne, ICRC Mezinarodni Ctr Klin Vyzkumu, Brno, Czech Republic

[3] Lekarska Fak, Brno, Czech Republic

[4] LF MU & FN Sv Anny Brne, Klin Zobrazovacich Metod, Brno, Czech Republic

[5] LF MU & FN Sv Anny Brne, Interni Klin 2, Brno, Czech Republic

[6] LF MU, Fyziol Ustav, Kamenice 5, Brno 62500, Czech Republic

来源：

CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE | 2016年 / 79卷 / 03期

关键词：

microRNA; ischemic stroke; intracranial aneurysma; cerebral arterio-venous malformations; FOCAL CEREBRAL-ISCHEMIA; UNRUPTURED INTRACRANIAL ANEURYSMS; DOWN-REGULATION; CELL-DEATH; CIRCULATING MICRORNAS; PROTECTS NEURONS; UP-REGULATION; MOUSE-BRAIN; EXPRESSION; STROKE;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Small non-coding molecules of ribonucleic acid are important regulators of gene expression and translation. One group of non-coding RNAs is represented by microRNA - 22-24 nucleotides long RNA molecules with effects on regulation of proteins synthesis. Many of them are tissue or organ specific (e.g. miR-206 in striated muscles or miR-122 in hepatocytes).These molecules are enzyme-resistant and detectable in both intracellular and extracellular space. Currently, these molecules are intensively studied as potential markers in many diseases including cerebrovascular diseases. In this review we provide insight into the recent knowledge from animal to human studies concerning miRNAs, with the special emphasis put on diagnostic, therapeutic and prognostic potentials in ischemic stroke (let-7, miR-7, miR-21, miR-29, miR-124, miR-181, miR-210, miR-223), intracranial aneurysms (miR-21, miR-26, miR-29, miR-143/145), and brain arterio-venous malformations (miR-18a).

引用

页码：287 / 293

页数：7

共 92 条

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