Polymorphism of transmembrane region of MICA gene and Kawasaki disease

被引:36
作者
Huang, FY
Lee, YJ
Chen, MR
Hsu, CH
Lin, SP
Sung, TC
Chang, SC
Chang, JG
机构
[1] China Med Coll Hosp, Dept Med Res, Div Mol Med, Taichung, Taiwan
[2] Mackay Mem Hosp, Dept Pediat, Taipei, Taiwan
[3] Mackay Mem Hosp, Dept Med Res, Taipei, Taiwan
[4] Taipei Med Coll, Dept Pediat, Taipei, Taiwan
[5] Shin Kong Wu Ho Su Mem Hosp, Dept Pediat, Taipei, Taiwan
关键词
Kawasaki disease; MICA; MHC-class-1-related gene A; transmembrane region of MICA; Chinese;
D O I
10.1159/000019132
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Kawasaki disease is a febrile disease of children complicated with vasculitis of the coronary arteries and potential aneurysm formation. It has been recognized worldwide and appears to be increasing in frequency. Studies have found that Kawasaki disease is associated with major histocompatibility complex (MHC) class I B antigens. The MHC-class-I-chain-related gene A (MICA) is located near HLA-B. It has a triplet repeat microsatellite polymorphism in the transmembrane region. We investigated the microsatellite polymorphism in children with Kawasaki disease and controls. Seventy children (46 boys), age at diagnosis 1.68 +/- 1.69 years, with Kawasaki who were treated with aspirin as well as intravenous gamma-globulin were enrolled. Control subjects consisted of 154 children (87 boys), age 2.81 +/- 2.12 years. Phenotype frequency of allele A4 in patients with aneurysm formation was significantly lower than in patients without aneurysms [relative risk (RR) = 0.06, 95% confidence interval (CI) = 0.01-0.48, p = 0.00469, pc = 0.0232] and showed a similar tendency when compared with controls. Gene frequency of allele A4 was also significantly lower in patients who developed aneurysms than in patients who did not (RR = 0.07, 95% CI = 0.01-0.57, p = 0.0057, pc = 0.0282). Gene frequency of allele A5 showed a tendency to be higher in patients who developed aneurysms than in controls (RR = 2.35, 95% CI = 0.98-5.63, p = 0.0486, pc = 0.220). Allele A5.1 tended to be negatively associated with Kawasaki disease (RR = 0.57, 95% CI = 0.35-0.93, p = 0.022, pc = 0.105). Our study showed that allele A4 was negatively associated with coronary aneurysm formation in Kawasaki disease. This suggests that allele A4 protects the children with Kawasaki disease from developing coronary aneurysms after aspirin and gamma globulin therapy. Copyright (C) 2000 S. Karger AG,Basel.
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页码:130 / 137
页数:8
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