Solid-phase synthesis of Δ2-isoxazolines

被引：36

作者：

Cheng, JF ^{[1
]}

Mjalli, AMM ^{[1
]}

机构：

[1] Ontogen Corp, Carlsbad, CA 92009 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(97)10700-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solid-phase synthesis of Delta(2)-isoxazolines through a 1,3-dipolar cycloaddition of nitrile oxides is described. The aldoxime is oxidized with commercially available bleach to give the corresponding nitrile oxide, which reacts in situ with dipolarophiles to afford Delta(2)-isoxazolines in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：939 / 942

页数：4

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