Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children's Study

被引：14

作者：

Kyozuka, Hyo ^{[1
,2
]}

Murata, Tsuyoshi ^{[1
,2
]}

Fukuda, Toma ^{[1
,2
]}

Endo, Yuta ^{[1
,2
]}

Yamaguchi, Akiko ^{[1
,2
]}

Yasuda, Shun ^{[1
,2
]}

Kanno, Aya ^{[1
,2
]}

Sato, Akiko ^{[2
]}

Ogata, Yuka ^{[2
]}

Hosoya, Mitsuaki ^{[2
,3
]}

Yasumura, Seiji ^{[2
,4
]}

Hashimoto, Koichi ^{[2
,3
]}

Nishigori, Hidekazu ^{[2
,5
]}

Fujimori, Keiya ^{[1
,2
]}

机构：

[1] Fukushima Med Univ, Dept Obstet & Gynecol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan

[2] Fukushima Med Univ, Sch Med, Fukushima Reg Ctr Japan Environm & Childrens Stud, 1 Hikarigaoka, Fukushima 9601295, Japan

[3] Fukushima Med Univ, Dept Pediat, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan

[4] Fukushima Med Univ, Dept Publ Hlth, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan

[5] Fukushima Med Univ, Fukushima Med Ctr Children & Women, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

SERUM IGE LEVELS; EARLY-ONSET; GESTATIONAL-AGE; MAST-CELL; PREECLAMPSIA; DISORDERS; BIOMARKERS; DISEASE; WOMEN; JECS;

D O I：

10.1038/s41598-021-88227-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

High serum immunoglobulin E (IgE) levels are associated with cardiovascular events. We aimed to evaluate the association between total IgE levels during the first trimester of pregnancy and pregnancy-induced hypertension (PIH) development in a large Japanese cohort. We analysed data pertaining to singleton primipara pregnancies recorded in the Japan Environment and Children's Study involving births from 2011 to 2014. Serum IgE levels were determined using the immunonephelometric technique. High serum IgE was defined as level >= 170 IU/ml. Hypertensive disorders in pregnancy (HDP) were categorized into early onset (Eo) PIH (developed<34 weeks) or late onset (Lo) PIH (developed 34 weeks). A multiple logistic regression model was used to estimate the risk of high serum IgE levels on PIH, Eo-PIH, and Lo-PIH. Overall, 32,518 participants were enrolled. The prevalence of total, Eo-, and Lo-PIH was 3.2%, 0.6%, and 2.3%, respectively. Patients with high serum IgE levels had an increased risk of Lo-HDP (adjusted odds ratio [aOR]:1.19, 95% confidence interval 1.01-1.40). No correlation was found with either PIH (total) or Eo-PIH. High serum IgE levels during the first trimester were associated with the risk of Lo-PIH. Our results could influence and shape further research regarding the pathogenesis of Lo hypertension.

引用

页数：9

共 44 条

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