Sphingosine-1-phosphate: An enigmatic signalling lipid

被引：1752
作者：
Spiegel, S
Milstien, S
机构：
[1] Virginia Commonwealth Univ, Dept Biochem, Richmond, VA 23298 USA
[2] NIMH, Lab Cellular & Mol Regulat, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 05期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1103
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.
引用
收藏
页码：397 / 407
页数：11
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