Palladium-Catalyzed Direct C-H Olefination of Polyfluoroarenes with Alkenyl Tosylates

被引：3

作者：

Yee, Ka Yee

Leung, Man Pan

Tse, Man Ho

Choy, Pui Ying

Kwong, Fuk Yee ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2022年 / 2022卷 / 25期

关键词：

Homogeneous catalysis; Olefination; Palladium; Phosphine ligands; Polyfluoroarenes; CROSS-COUPLING REACTIONS; ARYL MESYLATES; HECK REACTION; PHOSPHINE-LIGANDS; DIRECT ARYLATION; SUZUKI; SYSTEM; HETEROARYL;

D O I：

10.1002/ejic.202200288

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first general examples of palladium-catalyzed direct C-H olefination of polyfluoroarenes using alkenyl tosylates as electrophilic coupling partners are presented. By employing the Pd/L1 catalyst system (L1=N-methyl-2-(2',4'-dimethoxyphenyl)-3-dicyclohexylphosphinoindole), the olefinated polyfluoroarenes can be obtained in good-to-excellent yields. Good structural and functional compatibility are also exhibited. In particular, the steric demanding and heterocyclic alkenyl tosylates react smoothly under this catalyst system. This reaction can be practicably performed on a gram-scale without significantly loss of product yields.

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页数：10

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