Induced diarrhoea in horses part 1: Fluid and electrolyte balance

Sodium, potassium and water balance, and measurements of acid-base status, haematocrit, packed cell volume and plasma total protein, were studied in four adult standardbred geldings following castor oil induced diarrhoea. Castor oil (2 mL kg(-1)) administration resulted in signs consistent with mild to moderate acute colitis. The total (combined faecal and urinary losses) losses of sodium and potassium ions were 2169 and 2864 mmol, respectively. Faeces constituted the major route for sodium loss, while urine was the major route for potassium loss at all times. Faecal dr): matter potassium concentration did not vary significantly at any stage. Faecal dry matter sodium concentration increased significantly, coinciding with the onset of clinical diarrhoea. Faecal water loss increased significantly from 2.15+/-0.44 mL kg(-1) h(-1) to 5.15+/-0.92 mL kg(-1) h(-1) while clinical diarrhoea was observed. While plasma volume (PV) did not vary significantly in this study, there was a trend for PV to decrease while horses were clinically dehydrated.