Bone Morphogenetic Proteins: Indications and Uses

被引：19

作者：

Bibbo, Christopher ^{[1
,2
]}

Nelson, Jonas ^{[2
]}

Ehrlich, David ^{[3
]}

Rougeux, Brian ^{[1
]}

机构：

[1] Marshfield Clin Fdn Med Res & Educ, Dept Orthopaed, Marshfield, WI 54449 USA

[2] Hosp Univ Penn, Dept Surg, Div Plast & Reconstruct Surg, Philadelphia, PA 19104 USA

[3] Thomas Jefferson Univ, Dept Surg, Div Plast & Reconstruct Surg, Philadelphia, PA 19107 USA

来源：

CLINICS IN PODIATRIC MEDICINE AND SURGERY | 2015年 / 32卷 / 01期

关键词：

Bone morphogenetic protein; BMP; Foot and ankle surgery; Bone healing; OSTEOBLAST DIFFERENTIATION; RUNX2; DEGRADATION; SMURF1; CANCER; RISK; COMPLICATIONS; EXPRESSION; RECEPTORS; RHBMP-2; FUSION;

D O I：

10.1016/j.cpm.2014.09.005

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The bone morphogenetic proteins (BMPs) are an important subclass of growth factors within the transforming growth factor beta superfamily; BMP-2 and BMP-7 have important roles in bone healing. The most facile commercially available BMP for surgical use is recombinant BMP-2 (rhBMP-2). Although there are only a few studies that attest to the efficacy of rhBMP-2 to assist with bone healing in the foot and ankle literature, the data are compelling. This article presents the background, basic science, clinical indications, and outcomes for the use of BMP in foot and ankle surgery.

引用

页码：35 / +

页数：10

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