Dissecting the roles of the androgen receptor in prostate cancer from molecular perspectives

被引：21

作者：

Hu, Jieping ^{[1
]}

Wang, Gongxian ^{[1
]}

Sun, Ting ^{[1
]}

机构：

[1] Nanchang Univ, Dept Urol, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China

来源：

TUMOR BIOLOGY | 2017年 / 39卷 / 05期

关键词：

Androgen receptor; variants; translocation; dimerization; cell signals; NF-KAPPA-B; SPLICE VARIANTS; GENE-EXPRESSION; DOWN-REGULATION; BETA-RECEPTOR; TRANSFORMING GROWTH-FACTOR-BETA-1; TRANSCRIPTIONAL ACTIVITY; DEPRIVATION THERAPY; CELL-PROLIFERATION; SUPPRESS GROWTH;

D O I：

10.1177/1010428317692259

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Androgen receptor plays a pivotal role in prostate cancer progression, and androgen deprivation therapy to intercept androgen receptor signal pathway is an indispensable treatment for most advanced prostate cancer patients to delay cancer progression. However, the emerging of castration-resistant prostate cancer reminds us the alteration of androgen receptor, which includes androgen receptor mutation, the formation of androgen receptor variants, and androgen receptor distribution in cancer cells. In this review, we introduce the process of androgen receptor and also its variants' formation, translocation, and function alteration by protein modification or interaction with other pathways. We dissect the roles of androgen receptor in prostate cancer from molecular perspective to provide clues for battling prostate cancer, especially castration-resistant prostate cancer.

引用

页数：15

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