Bone formation at the surface of low modulus Ti-7.5Mo implants in rabbit femur

被引:97
作者
Lin, Dan-Jae
Chuang, Cheng-Chung
Lin, Jiin-Huey Chern
Lee, Jing-Wei
Ju, Chien-Ping
Yin, Hsiang-Shu [1 ]
机构
[1] Natl Taiwan Univ, Coll Med, Dept Anat & Cell Biol, Taipei 100, Taiwan
[2] Natl Cheng Kung Univ, Dept Mat Sci & Engn, Tainan 70101, Taiwan
[3] Natl Cheng Kung Univ Hosp, Dept Surg, Div Plast Surg, Tainan 701, Taiwan
关键词
cell viability; implantation to femur; bone growth; bone marrow; bioabsorption;
D O I
10.1016/j.biomaterials.2007.02.005
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The biocompatibility of the Ti-7.5Mo alloy was examined, because the alloy has a high-strength/modulus ratio and thus is a potential candidate for orthopedic applications. Cell viability assay using 3T3 cells revealed that the Ti-7.5Mo did not induce apparent cell death, when the cells were grown on disks made of the alloy or incubated with the alloy-conditioned medium at 37 or 72 degrees C for 24-72 h. The Ti-6Al-4V alloy was used as a control and did not cause apparent cell death either. Moreover, pins of 6 mm long and 2 mm in diameter of Ti-7.5Mo and Ti-6Al-4V were implanted into the left and right rabbit femurs, respectively, for 6, 12 and 26 weeks. New bone tissue grew to surround the pins, which spanned cortical and marrow regions, as shown by toluidine blue-stained bone sections of the three time points. Strikingly, the amount of new bone encircling the Ti-7.5Mo implant was approximate two-folds of that at Ti-6Al-4V by 26 weeks post-implantation. This facilitation of bone formation could be associated with the unique properties, such as a low modulus and the composition of Mo, of the Ti-7.5Mo. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2582 / 2589
页数:8
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