Catalysis in Transamination of 6-chloro-2-(3-chlorophenyl)-1H-benz[de]isoquinoline-1,3-(2H)-dione and its Implications in Laser Tissue Welding

被引：2
|
作者：
Anderson, Samantha M. [1 ]
Mitchell, Stanford D. [1 ]
LaPlante, Kayla A. [1 ]
McKenney, Ryan K. [1 ]
Lewis, David E. [1 ]
机构：
[1] Univ Wisconsin, Dept Chem, Eau Claire, WI 54702 USA
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 03期
关键词：
1,8-NAPHTHALIMIDE; NAPHTHALIMIDE; INHIBITION;
D O I：
10.1002/jhet.2800
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The transamination of 6-chloro-2-(3-chlorophenyl)-1H-benz[de]isoquinoline-1,3-(2H)-dione with primary alkylamines under pseudo-first-order conditions is shown to be unimolecular in both reagents as well as unimolecular in methanol (in methanol solution). The reaction is subject to both general acid and general base catalysis. A termolecular, solvated transition state model and a putative model for the early steps of laser tissue welding with aminonaphthalimide dyes are proposed.
引用
收藏
页码：2029 / 2037
页数：9
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