Intrathecal synthesis of onconeural antibodies in patients with paraneoplastic syndromes

被引：9

作者：

Corsini, Elena ^{[1
]}

Gaviani, Paola ^{[2
]}

Chiapparini, Luisa ^{[3
]}

Lazzaroni, Monica ^{[1
]}

Ciusani, Emilio ^{[1
]}

Bisogno, Raffaele ^{[3
]}

Silvani, Antonio ^{[2
]}

Salmaggi, Andrea ^{[4
]}

Bernardi, Gaetano ^{[1
]}

机构：

[1] Fdn IRCCS Neurol Inst C Besta, Lab Clin Pathol & Med Genet, Via Celoria 11, I-20133 Milan, Italy

[2] Fdn IRCCS Neurol Inst C Besta, Dept Clin Neurosci, Unit Neurooncol, Via Celoria 11, I-20133 Milan, Italy

[3] Fdn IRCCS Neurol Inst C Besta, Dept Neuroradiol, Via Celoria 11, I-20133 Milan, Italy

[4] A Manzoni Hosp, Dept Neurol, Via dellEremo 9-11, I-23900 Lecce, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 290卷

关键词：

Onconeural antibodies; Paraneoplastic neurological syndromes; Cerebrospinal fluid; MRI; Intrathecal synthesis; NEUROLOGICAL SYNDROMES; CEREBROSPINAL-FLUID; HU ANTIBODY; SERUM;

D O I：

10.1016/j.jneuroim.2015.11.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Paraneoplastic neurological syndromes (PNSs) are a group of immune-mediated neurological disorders occurring in patients with systemic cancers which are associated with the presence of anti-neuronal antibodies. In this retrospective study, serum and cerebrospinal fluid of 489 patients were analyzed for the presence of well characterized onconeural antibodies. The 18 PNS patients positive for onconeural antibodies were reanalyzed to evaluate possible intrathecal synthesis. Intrathecal synthesis of onconeural antibodies, was detected in 10/15 patients affected by PNSs involving the CNS and in 1/3 cases with peripheral syndromes. Our data confirm that onconeural antibodies are produced within the CNS in most PNS patients. Evaluation of intrathecal synthesis of onconeural antibodies on a larger cohort of PNS patients and the correlation with disease course might elucidate whether this marker has a value in predicting the prognosis of the neurological disease. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：119 / 122

页数：4

共 12 条

[1] Paraneoplastic syndromes of the CNS [J].

Dalmau, Josep ;

Rosenfeld, Myrna R. .

LANCET NEUROLOGY, 2008, 7 (04) :327-340

[2] Paraneoplastic syndromes involving the nervous system [J].

Darnell, RB ;

Posner, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (16) :1543-1554

[3]

Graus F, 2004, J NEUROL NEUROSUR PS, V75, P1135, DOI 10.1136/jnnp.2003.034447

[4] Paraneoplastic neurological syndromes [J].

Graus, Francesc ;

Dalmau, Josep .

CURRENT OPINION IN NEUROLOGY, 2012, 25 (06) :795-801

[5] Positivity of serum "classical" onconeural antibodies in a series of 2063 consecutive patients with suspicion of paraneoplastic neurological syndrome [J].

Gromadzka, Grazyna ;

Karlinska, Anna G. ;

Lysiak, Zofia ;

Blazejewska-Hyzorek, Beata ;

Litwin, Tomasz ;

Czlonkowska, Anna .

JOURNAL OF NEUROIMMUNOLOGY, 2013, 259 (1-2) :75-80

[6] Value of Hu antibody determinations in the follow-up of paraneoplastic neurologic syndromes [J].

Lladó, A ;

Mannucci, P ;

Carpentier, AF ;

Paris, S ;

Blanco, Y ;

Saiz, A ;

Delattre, JY ;

Graus, F .

NEUROLOGY, 2004, 63 (10) :1947-1949

[7] Cerebrospinal fluid study in paraneoplastic syndromes [J].

Psimaras, D. ;

Carpentier, A. F. ;

Rossi, C. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 (01) :42-45

[8] Dynamics of brain-derived proteins in cerebrospinal fluid [J].

Reiber, H .

CLINICA CHIMICA ACTA, 2001, 310 (02) :173-186

[9] Antigen-specific oligoclonal bands in cerebrospinal fluid and serum from patients with anti-amphiphysin- and anti-CV2/CRMP5 associated paraneoplastic neurological syndromes [J].

Stich, O. ;

Rauer, S. .

EUROPEAN JOURNAL OF NEUROLOGY, 2007, 14 (06) :650-653

[10] Limbic encephalitis and variants:: Classification, diagnosis and treatment [J].

Tuzun, Erdem ;

Dalmau, Josep .

NEUROLOGIST, 2007, 13 (05) :261-271

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