Hypercaloric diet contribues to beta cell apoptosis in type 2 diabetes

被引：4

作者：

Miricescu, Daniela ^{[1
]}

Stanescu, Ana Maria Alexandra ^{[2
]}

Lazarescu, Horia ^{[3
]}

Kozma, Andrei ^{[3
,4
]}

Totan, Alexandra ^{[1
]}

Stefani, Constantin ^{[2
,5
]}

Radulescu, Radu ^{[1
]}

Greabu, Maria ^{[1
]}

机构：

[1] Carol Davila Univ Med & Pharm, Fac Dent Med, Dept Biochem, Bucharest, Romania

[2] Carol Davila Univ Med & Pharm, Fac Dent Med, Dept Family Med, Bucharest, Romania

[3] Natl Inst Recovery Phys Med & Balneoclimathol, Bucharest, Romania

[4] Alessandrescu Rusescu Natl Inst Mother & Child Hl, Bucharest, Romania

[5] Carol Davila Univ, Cent Emergency Mil Hosp, Bucharest, Romania

来源：

ROMANIAN JOURNAL OF LEGAL MEDICINE | 2019年 / 27卷 / 03期

关键词：

hypercaloric diet; Beta cell apoptosis; type; 2; diabetes; FREE FATTY-ACIDS; BH3-ONLY PROTEINS; OXIDATIVE STRESS; GLUCOSE; OBESITY; DEATH; INFLAMMASOME; ACTIVATION; MECHANISMS; IL-1-BETA;

D O I：

10.4323/rjlm.2019.217

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A diet rich in saturated fats, refined carbohydrates, poor in fruits and vegetables, associated with a sedentary life leads to obesity. According to statistical data, the incidence of obesity among children, adolescents and adults has increased dramatically in the last 20 years both in the USA and in Europe. Obesity has many negative effects on the human body, being involved in the pathogenesis of type 2 diabetes, cardiovascular diseases and cancer. An important feature of type 2 diabetes is represented by pancreatic beta-cell apoptosis. Hyperglycemia and hyperlipidemia causes beta-cell dysfunction and may induce apoptosis in type 2 diabetes. Apoptosis can occur through two major pathways, the extrinsic (death receptor mediated pathway) and intrinsic pathway (involves the regulation of Blc-2). The purpose of this review is to present the mechanisms by which the hypercaloric diet can induce apoptosis of pancreatic beta cells.

引用

页码：217 / 220

页数：4

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