Medicinal and Biological Significance of Phenoxazine Derivatives

被引：14
|
作者：
Shruti [1 ]
Dwivedi, Jaya [1 ]
Neetu [1 ]
Jain, Sonika [1 ]
机构：
[1] Banasthali Vidyapith, Dept Chem, Banasthali 304022, Rajasthan, India
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2021年 / 21卷 / 12期
关键词：
Phenoxazine derivatives; pharmacological activity; biological significance; anticancer; antitumor; reactivity; synthesis; CANCER CELL-LINES; ANTICANCER ACTIVITY; IN-VITRO; APOPTOSIS; PHENOTHIAZINE; GROWTH; 2-AMINOPHENOXAZINE-3-ONE; DEATH; DYES;
D O I：
10.2174/1389557520666201214102151
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Since 1887, phenoxazine derivatives have attracted the attention of chemists due to their versatile utility, industrially and pharmacologically. Literature is found abundant with various pharmacological activities of phenoxazine derivatives like antitumor, anticancer, antifungal, antibacterial, anti-inflammatory, anti-diabetic, anti-viral, anti-malarial, anti-depressant, analgesic and many other drug resistance reversal activities. This review covers a detailed overview of the pharmacological application of phenoxazine nucleus, its chemistry and reactivity, and also illustrating the incorporation of different groups at different positions enhancing its biological application, besides some synthetic procedures.
引用
收藏
页码：1541 / 1555
页数：15
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