Adoptive T cell therapy of cancer

被引：101

作者：

Brenner, Malcolm K.

Heslop, Helen E. ^{[1
]}

机构：

[1] Baylor Coll Med, Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 02期

关键词：

CHIMERIC ANTIGEN RECEPTOR; ANTITUMOR-ACTIVITY; METASTATIC MELANOMA; EFFECTOR-CELLS; SUICIDE-GENE; PHASE-I; LYMPHOCYTES; LEUKEMIA; MEMORY; TCR;

D O I：

10.1016/j.coi.2010.01.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies. Current research focuses on defining the optimum type of cell for transfer, genetically modifying infused T cells to augment function and overcome tumor evasion strategies and modulating the host environment.

引用

页码：251 / 257

页数：7

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