HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells

被引：68
作者：
Li Chushi [1 ]
Wu Wei [1 ]
Xie Kangkang [1 ]
Feng Yongzeng [2 ]
Xie Ning [1 ]
Chen Xiaolei [3 ]
机构：
[1] Cangnan Cty Peoples Hosp, City Of Wenzhou 325800, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 2, City Of Wenzhou 325800, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, City Of Wenzhou 325800, Zhejiang, Peoples R China
来源：
GENE | 2016年 / 587卷 / 01期
关键词：
Gastric cancer; HMGCR; Cell growth and migration; Hedgehog/Glil signaling; SONIC HEDGEHOG; PATHWAY;
D O I：
10.1016/j.gene.2016.04.029
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Alteration of metabolic profile is one of the hallmarks of cancer cells. Statin, the inhibitors for synthesis of cholesterol, has shown anti-cancer effects on the gastric cancer cells. However, the functions of its target, HMGCR, in the progression of gastric cancer remain unknown. In the present study, we investigated the expression profile and the biological functions of HMGCR in gastric cancer. It was found that the expression of HMGCR was increased in gastric cancer tissues. Over-expression of HMGCR promoted the growth and migration of gastric cancer cells, while knocking down the expression of HMGCR inhibited the growth, migration and tumorigenesis of gastric cancer cells. In the further molecular mechanism study, HMGCR was shown to activate Hedgehog/Gli1 signaling and promoted the expression of Gli1 target genes. Taken together, this study demonstrated the tumor-promoting effects of HMGCR in gastric cancer and suggested HMGCR as a promising therapeutic target. (C) 2016 Published by Elsevier B.V.
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收藏
页码：42 / 47
页数：6
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