Natural history of stenosis from intracranial atherosclerosis by serial angiography

被引:106
作者
Akins, PT
Pilgram, TK
Cross, DT
Moran, CJ
机构
[1] Mercy Healthcare Sacramento, Sacramento, CA 95816 USA
[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, Neuroradiol Sect, St Louis, MO 63110 USA
关键词
angioplasty; atherosclerosis; cerebral angiography; cerebral ischemia; transient;
D O I
10.1161/01.STR.29.2.433
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-Knowledge of the natural history of stenoses due to intracranial atherosclerosis may be useful for evaluating possible treatments such as angioplasty. Methods-We retrospectively reviewed records over a 7-year period to identify patients with intracranial atherosclerotic stenoses and serial angiograms. Quantitative measurements of stenoses were made in a blinded manner, and clinical outcomes were reviewed. Results-We identified 21 patients with 45 intracranial stenoses who underwent repeat angiography at an average interval of 26.7 months. The average stenosis for all intracranial lesions was 43.9% initially and 51.8% on follow-up (P=.032). The average stenosis in the intracranial internal carotid artery (ICA) was stable (51.2% versus 52.6%). The average stenosis in the anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA) progressed from 32.4% to 49.7% (P=.037). Based on a minimum 10%, change, 20% of intracranial ICA lesions progressed compared with 61% of ACA, MCA, and PCA lesions. Regression occurred in 14% of the intracranial ICA group and 28% of the ACA-MCA-PCA group. Cerebrovascular events were infrequent during this period, with 4 transient ischemic attacks and 1 intracerebral hemorrhage. Conclusions-Intracranial atherosclerotic stenoses are dynamic lesions demonstrating both progression and regression.
引用
收藏
页码:433 / 438
页数:6
相关论文
共 30 条
[1]   CHANGES IN INTRACRANIAL STENOTIC LESIONS AFTER EXTRACRANIAL-INTRACRANIAL BYPASS-SURGERY [J].
AWAD, I ;
FURLAN, AJ ;
LITTLE, JR .
JOURNAL OF NEUROSURGERY, 1984, 60 (04) :771-776
[2]   Progression of coronary artery disease predicts clinical coronary events - Long-term follow-up from the Cholesterol Lowering Atherosclerosis Study [J].
Azen, SP ;
Mack, WJ ;
CashinHemphill, L ;
LaBree, L ;
Shircore, AM ;
Selzer, RH ;
Blankenhorn, DH ;
Hodis, HN .
CIRCULATION, 1996, 93 (01) :34-41
[4]  
BAUER RB, 1968, AMER J ROENTGENOL RA, V104, P1
[5]   ARTERIAL IMAGING AND ATHEROSCLEROSIS REVERSAL [J].
BLANKENHORN, DH ;
HODIS, HN .
ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (02) :177-192
[6]   PROGNOSIS OF SYMPTOMATIC INTRACRANIAL OBSTRUCTION OF INTERNAL CAROTID-ARTERY [J].
BOGOUSSLAVSKY, J ;
REGLI, F .
EUROPEAN NEUROLOGY, 1983, 22 (05) :351-358
[7]   CHANGES IN SEQUENTIAL CORONARY ARTERIOGRAMS AND SUBSEQUENT CORONARY EVENTS [J].
BUCHWALD, H ;
MATTS, JP ;
FITCH, LL ;
CAMPOS, CT ;
SANMARCO, ME ;
AMPLATZ, K ;
CASTANEDAZUNIGA, WR ;
HUNTER, DW ;
PEARCE, MB ;
BISSETT, JK ;
EDMISTON, WA ;
SAWIN, HS ;
WEBER, FJ ;
VARCO, RL ;
CAMPBELL, GS ;
YELLIN, AE ;
SMINK, RD ;
LONG, JM ;
HANSEN, BJ ;
CHALMERS, TC ;
MEIER, P ;
STAMLER, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 268 (11) :1429-1433
[8]   RACE, SEX AND OCCLUSIVE CEREBROVASCULAR-DISEASE - A REVIEW [J].
CAPLAN, LR ;
GORELICK, PB ;
HIER, DB .
STROKE, 1986, 17 (04) :648-655
[9]   THE WARFARIN-ASPIRIN SYMPTOMATIC INTRACRANIAL DISEASE STUDY [J].
CHIMOWITZ, MI ;
KOKKINOS, J ;
STRONG, J ;
BROWN, MB ;
LEVINE, SR ;
SILLIMAN, S ;
PESSIN, MS ;
WEICHEL, E ;
SILA, CA ;
FURLAN, AJ ;
KARGMAN, DE ;
SACCO, RL ;
WITYK, RJ ;
FORD, G ;
FAYAD, PB .
NEUROLOGY, 1995, 45 (08) :1488-1493
[10]   SAFETY AND EFFICACY OF PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY FOR INTRACRANIAL ATHEROSCLEROTIC STENOSIS [J].
CLARK, WM ;
BARNWELL, SL ;
NESBIT, G ;
ONEILL, OR ;
WYNN, ML ;
COULL, BM .
STROKE, 1995, 26 (07) :1200-1204